Introduction：Basic information about CAS 67700-30-5|furaprofen, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | furaprofen |
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| CAS Number | 67700-30-5 | Molecular Weight | 266.29100 |
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| Density | 1.23g/cm3 | Boiling Point | 449.4ºC at 760 mmHg |
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| Molecular Formula | C17H14O3 | Melting Point | / |
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| MSDS | / | Flash Point | 225.6ºC |
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Names
| Name | furaprofen |
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| Synonym | More Synonyms |
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furaprofen BiologicalActivity
| Description | R803 is an effective HCV replication inhibitor. R803 is substantially more potent against genotype 1a and 1b replicons (EC50, ~30 nM) than against the genotype 2a replicon (EC50, ~1,000 nM). |
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| Related Catalog | Signaling Pathways >>Anti-infection >>HCVResearch Areas >>Infection |
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| Target | EC50: ~30 nM (HCV genotype 1a and 1b replicons), ~1000 nM (HCV genotype 2a replicon)[1] |
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| In Vitro | R803 is potent and highly specific for HCV replication. The antiviral activity of R803 has been determined by a reporter replicon assay with multiple repeats to be 29.88±8.05 nM, an ~3-fold improvement over the activity of the parent compound, R706. The potency of R803 against the replicon is also confirmed by both Western blotting and TaqMan RT-PCR to be about 37 nM and 54.67±4.11 nM, respectively . To assess the general effect of R803 on cell proliferation, a panel of primary cells and transformed human cell lines are treated with increasing doses of R803 for 48 h, and the effect on cell proliferation is measured by an MTS-based cell viability assay. The the concentration that caused a 50% reduction in cell numbers in the absence of virus infection (CC50) of R803 is found to range from 2 μM to ≥10 μM, depending on the cell type and proliferation status[1]. |
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| Kinase Assay | Plasmid PV-Luc is linearized with the PvuI restriction enzyme and subjected to in vitro transcription using the RiboMAX Large Scale RNA Production System-T7. After DNase I digestion and purification, the transcribed RNA (5 μg) is electroporated into Huh-7 cells at 270 V and 950 μF on a Gene Pulser II system. The cells are then dispensed into white 96-well plates at a density of 10,000/90 μL/well. R803 is serially diluted in compound diluent (10% DMSO, 20% methanol) and added to each well in a volume of 10 μL. The plates are incubated for 18 h at 37°C under 5% CO2 before luciferase activity is determined using the Bright-Glo luciferase assay kit[1]. |
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| Cell Assay | Replicon 9-13 cells are plated onto 6-well plates 24 h prior to the treatment. Serial dilutions of R803 are made in a mixture containing 90% of the culture medium, 7.2% 1× PBS, 1.8% methanol, 1% DMSO, 20 μM RBV, and varying concentrations of IFN-α for a fixed-ratio dose-response study. The cells are treated with the designated combinations of R803 (0 to 80 nM concentrations) and IFN-α (0 to 4 IU/mL) plus 20 μM RBV for 72 h; then they are washed with PBS, lysed in SDS loading buffer, and analyzed by Western blotting[1]. |
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| References | [1]. Huang P, et al. Discovery and characterization of substituted diphenyl heterocyclic compounds as potent and selective inhibitors of hepatitis C virus replication. Antimicrob Agents Chemother. 2008 Apr;52(4):1419-29. |
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Chemical & Physical Properties
| Density | 1.23g/cm3 |
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| Boiling Point | 449.4ºC at 760 mmHg |
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| Molecular Formula | C17H14O3 |
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| Molecular Weight | 266.29100 |
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| Flash Point | 225.6ºC |
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| Exact Mass | 266.09400 |
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| PSA | 50.44000 |
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| LogP | 4.28790 |
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| Index of Refraction | 1.627 |
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| InChIKey | ODZUWQAFWMLWCF-UHFFFAOYSA-N |
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| SMILES | CC(C(=O)O)c1cccc2c(-c3ccccc3)coc12 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DF6424000
- CHEMICAL NAME :
- 7-Benzofuranacetic acid, alpha-methyl-3-phenyl-, (+-)-
- CAS REGISTRY NUMBER :
- 67700-30-5
- LAST UPDATED :
- 199109
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C17-H14-O3
- MOLECULAR WEIGHT :
- 266.31
- WISWESSER LINE NOTATION :
- T56 BOJ DR& IY1&VQ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes
- REFERENCE :
- JCPCBR Journal of Clinical Pharmacology. (Hall Assoc., PO Box 482, Stamford, CT 06904) V.13- 1973- Volume(issue)/page/year: 16,473,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 950 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 214,240,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >1400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 214,240,1975
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Synonyms
