Introduction：Basic information about CAS 4366-18-1|Coumetarol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Coumetarol |
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| CAS Number | 4366-18-1 | Molecular Weight | 380.34800 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C21H16O7 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-hydroxy-3-[1-(4-hydroxy-2-oxochromen-3-yl)-2-methoxyethyl]chromen-2-one |
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| Synonym | More Synonyms |
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Coumetarol BiologicalActivity
| Description | Coumetarol is a vitamin K antagonist. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
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| Target | vitamin K[1] |
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| In Vitro | Coumetarol (Dicumoxane), an oral anticoagulant, is active in both models. The vitamin K antagonist Coumetarol is effective in both models after oral treatment but inhibits the thrombus formation more strongly in the arterio-venous shunt model. Treatment with the vitamin K antagonist Coumetarol in a dose of 25 mg/kg p.o. twice daily for 2 days results in a significant reduction in thrombus weight by 50% in the venous stasis model and by 75% in the arterio-venous shunt model. In both experiments the coagulation time as measured by the Thrombotest is prolonged to the same extent[1]. |
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| References | [1]. Vogel GM, et al. Comparison of two experimental thrombosis models in rats effects of four glycosaminoglycans. Thromb Res. 1989 Jun 1;54(5):399-410. |
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Chemical & Physical Properties
| Molecular Formula | C21H16O7 |
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| Molecular Weight | 380.34800 |
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| Exact Mass | 380.09000 |
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| PSA | 110.11000 |
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| LogP | 3.08890 |
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| InChIKey | BUCJFFQZPGTGPX-UHFFFAOYSA-N |
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| SMILES | COCC(c1c(O)c2ccccc2oc1=O)c1c(O)c2ccccc2oc1=O |
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Safety Information
| RIDADR | UN 2811 |
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| HS Code | 2932209090 |
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Customs
| HS Code | 2932209090 |
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| Summary | 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Cumetarolo |
| 3,3'-(2-methoxyethane-1,1-diyl)bis(2-hydroxy-4h-chromen-4-one) |
| Cumetharol |
| Cumetarol |
| 4,4'-dihydroxy-3,3'-(2-methoxy-ethane-1,1-diyl)-bis-chromen-2-one |
| 1,1-Bis-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-methoxy-aethan |
| Cumetarolo [DCIT] |
| 1,1-bis-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-methoxy-ethane |
| Coumetarolum |
| Coumetarol |
| UNII-UO1VQB3SPZ |
