CAS 154525-25-4|Uroguanylin Topoisomer A (human) trifluoroacetate salt
| Common Name | Uroguanylin Topoisomer A (human) trifluoroacetate salt | ||
|---|---|---|---|
| CAS Number | 154525-25-4 | Molecular Weight | 1667.86000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C64H102N18O26S4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | asn-asp-asp-cys-glu-leu-cys-val-asn-val-ala-cys-thr-gly-cys-leu |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | Uroguanylin (human) is a natural ligand for the Guanylyl Cyclase (GCC) receptor expressed in metastatic colorectal cancer tumors. Uroguanylin (human) has anti-tumor actions in an animal model for human colon cancer[1][2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>GPCR/G Protein >>Guanylate Cyclase |
| References | [1]. Lewis DK, et al. Hypertrehalosemic hormone in a cockroach: molecular cloning and expression. Mol Cell Endocrinol. 1997;130(1-2):101-108. |
Chemical & Physical Properties
| Molecular Formula | C64H102N18O26S4 |
|---|---|
| Molecular Weight | 1667.86000 |
| Exact Mass | 1666.61000 |
| PSA | 819.33000 |
| InChIKey | VQZRYOAXGUCZMI-HWMZBCIHSA-N |
| SMILES | CC(C)CC(NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(N)CC(N)=O)CSSCC(NC(=O)C(C)NC(=O)C(C(C)C)NC(=O)C(CC(N)=O)NC(=O)C(C(C)C)NC2=O)C(=O)NC(C(C)O)C(=O)NCC(=O)N1)C(=O)O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles7
More Articles| Characterization of immunological cross-reactivity between enterotoxigenic Escherichia coli heat-stable toxin and human guanylin and uroguanylin. Infect. Immun. 82(7) , 2913-22, (2014) Enterotoxigenic Escherichia coli (ETEC) expressing the heat-stable toxin (ST) (human-type [STh] and porcine-type [STp] variants) is among the five most important enteric pathogens in young children li... | |
| A uroguanylin-GUCY2C endocrine axis regulates feeding in mice. J. Clin. Invest. 121 , 3578-3588, (2011) Intestinal enteroendocrine cells are critical to central regulation of caloric consumption, since they activate hypothalamic circuits that decrease appetite and thereby restrict meal size by secreting... | |
| Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase. Proc. Natl. Acad. Sci. U. S. A. 90 , 10464, (1993) The intestinal hormone guanylin and bacterial heat-stable enterotoxins (STs) are members of a peptide family that activates intestinal membrane guanylate cyclase. Two different peptides that activate ... |
Synonyms
| asn-asp-asp-cys-glu-leu-cys-val-asn-val-ala-cys-thr-gly-cys-leu [disulfide bridges: 4-12,7-15] |
| UGN (HUMAN) |
| Uroguanylin (huMan)UGN (huMan) |
| UROGUANYLIN |
| Uroguanylin |
| UROGUANYLIN (HUMAN) |
