Introduction：Basic information about CAS 578-76-7|7-Methylguanine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 7-Methylguanine |
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| CAS Number | 578-76-7 | Molecular Weight | 165.153 |
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| Density | 1.8±0.1 g/cm3 | Boiling Point | 481.4±37.0 °C at 760 mmHg |
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| Molecular Formula | C6H7N5O | Melting Point | 370°C |
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| MSDS | / | Flash Point | 244.9±26.5 °C |
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Names
| Name | 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one |
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| Synonym | More Synonyms |
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7-Methylguanine BiologicalActivity
| Description | 7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method. |
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| Related Catalog | Natural Products >>OthersResearch Areas >>Others |
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| Target | Human Endogenous Metabolite |
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| References | [1]. Lee S, et al. Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. J Am Chem Soc. 2008 Sep 3;130(35):11570-1. |
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Chemical & Physical Properties
| Density | 1.8±0.1 g/cm3 |
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| Boiling Point | 481.4±37.0 °C at 760 mmHg |
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| Melting Point | 370°C |
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| Molecular Formula | C6H7N5O |
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| Molecular Weight | 165.153 |
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| Flash Point | 244.9±26.5 °C |
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| Exact Mass | 165.065063 |
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| PSA | 89.59000 |
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| LogP | -2.08 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.865 |
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| Storage condition | −20°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- MF8464000
- CHEMICAL NAME :
- Guanine, 7-methyl-
- CAS REGISTRY NUMBER :
- 578-76-7
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C6-H7-N5-O
- MOLECULAR WEIGHT :
- 165.18
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- Phage inhibition capacity
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 1 gm/L
- REFERENCE :
- ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.1- 1960- Volume(issue)/page/year: 12,583,1972
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Safety Information
| Hazard Codes | Xi |
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| WGK Germany | 3 |
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| RTECS | MF8464000 |
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Synonyms
| 6H-Purin-6-one, 2-amino-1,7-dihydro-7-methyl- |
| 2-amino-7-methyl-3H-purin-6-one |
| 2-Amino-7-methyl-1,7-dihydro-6H-purin-6-one |
| 7-methyl-Guanine (8CI) |
| 7-N-methylguanine |
| N(sup 7)-Methylguanine |
| 7-methyl-Guanine |
| Epiguanine |
| 2-Amino-7-methylhypoxanthine |
| N7-Methylguanine |
| 7-Methylguanine |
| 2-amino-7-methyl-1,7-dihydro-purin-6-one |
| 2-Amino-1,7-dihydro-7-methyl-6H-purin-6-one |
| GUANINE,7-METHYL |
| 2-Amino-6-hydroxy-7-methylpurine |
