Introduction：Basic information about CAS 67199-66-0|Bay H 2049, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Bay H 2049 |
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| CAS Number | 67199-66-0 | Molecular Weight | 249.27 |
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| Density | 1.46g/cm3 | Boiling Point | 524ºC at 760 mmHg |
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| Molecular Formula | C15H11N3O | Melting Point | / |
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| MSDS | / | Flash Point | 270.7ºC |
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Names
| Name | 8-amino-10H-isoindolo[1,2-b]quinazolin-12-one |
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| Synonym | More Synonyms |
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Bay H 2049 BiologicalActivity
| Description | Batracylin (NSC320846) is a potent DNA Topoisomerases I and DNA Topoisomerases II inhibitor. Batracylin shows cytotoxicity and antiproliferative activity. Batracylin induces DNA breaks[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Topoisomerase |
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| References | [1]. Rao VA, et al. Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage. Cancer Res. 2007 Oct 15;67(20):9971-9. |
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Chemical & Physical Properties
| Density | 1.46g/cm3 |
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| Boiling Point | 524ºC at 760 mmHg |
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| Molecular Formula | C15H11N3O |
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| Molecular Weight | 249.27 |
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| Flash Point | 270.7ºC |
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| Exact Mass | 249.09000 |
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| PSA | 58.69000 |
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| LogP | 2.27120 |
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| Index of Refraction | 1.781 |
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| InChIKey | SRIOCKJKFXAKHK-UHFFFAOYSA-N |
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| SMILES | Nc1ccc2c(c1)CN1C(=O)c3ccccc3C1=N2 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NR3900000
- CHEMICAL NAME :
- Isoindolo(1,2-b)quinazolin-12(10H)-one, 8-amino-
- CAS REGISTRY NUMBER :
- 67199-66-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C15-H11-N3-O
- MOLECULAR WEIGHT :
- 249.29
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 1 umol/L
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 126,39,1994
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Synonyms
| batracyclin |
| Batracylin |
| Daniquidona [INN-Spanish] |
| 8-aminoisoindolo<1,2-b>quinazolin-12(10H)-one |
| Isoindolo(1,2-b)quinazolin-12(10H)-one,8-amino |
| Daniquidonum [INN-Latin] |
| Daniquidone |
