Introduction：Basic information about CAS 801-52-5|Porfiromycin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Porfiromycin |
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| CAS Number | 801-52-5 | Molecular Weight | 348.35400 |
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| Density | 1.52g/cm3 | Boiling Point | 560.9ºC at 760 mmHg |
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| Molecular Formula | C16H20N4O5 | Melting Point | / |
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| MSDS | / | Flash Point | 293ºC |
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Names
| Name | Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-,(1aS,8S,8aR,8bS) |
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| Synonym | More Synonyms |
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Porfiromycin BiologicalActivity
| Description | Porfiromycin is a bioreductive alkylating agent that preferentially kill hypoxic tumor cells relative to other aerobic counterparts. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>DNA Alkylator/Crosslinker |
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| References | [1]. Keyes SR, Rockwell S, Sartorelli AC. Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro. Cancer Res. 1985;45(8):3642-3645. |
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Chemical & Physical Properties
| Density | 1.52g/cm3 |
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| Boiling Point | 560.9ºC at 760 mmHg |
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| Molecular Formula | C16H20N4O5 |
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| Molecular Weight | 348.35400 |
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| Flash Point | 293ºC |
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| Exact Mass | 348.14300 |
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| PSA | 127.96000 |
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| Index of Refraction | 1.672 |
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| InChIKey | HRHKSTOGXBBQCB-VFWICMBZSA-N |
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| SMILES | COC12C(COC(N)=O)C3=C(C(=O)C(C)=C(N)C3=O)N1CC1C2N1C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CN0525000
- CAS REGISTRY NUMBER :
- 801-52-5
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C16-H20-N4-O5
- MOLECULAR WEIGHT :
- 348.40
- WISWESSER LINE NOTATION :
- T D3 B556 BN EN JV MVTTT&J E1 GO1 H1OVZ KZ L1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 1500 ug/kg
- TOXIC EFFECTS :
- Blood - leukopenia Blood - thrombocytopenia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 68 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 88660 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 44 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 53500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 55 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Blood - granulocytopenia
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- >10 mg/kg
- TOXIC EFFECTS :
- Blood - granulocytopenia
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 84 mg/kg/28D-I
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death
MUTATION DATA - TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 2 umol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 46,3939,1986
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Synonyms
| N-methylmitomycin C |
| porphiromycin |
| Methyl MitoMycin C |
| Methylmitomycin |
| RegaMycin |
| Porfiromycine |
| porfiromycin |
| 8-Azathioxanthine |
