Introduction：Basic information about CAS 6834-98-6|Lagosin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Lagosin |
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| CAS Number | 6834-98-6 | Molecular Weight | 670.83 |
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| Density | 1.196g/cm3 | Boiling Point | 914ºC at 760 mmHg |
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| Molecular Formula | C35H58O12 | Melting Point | / |
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| MSDS | / | Flash Point | 278.4ºC |
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Names
| Name | (3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,15,16,27-nonahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one |
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| Synonym | More Synonyms |
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Lagosin BiologicalActivity
| Description | Lagosin (Fungichromin) is a polyene macrolide antibiotic. Lagosin has demonstrated broad-spectrum antifungal activity and is impervious to drug resistance[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Anti-infection >>Fungal |
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| In Vitro | Lagosin production by Streptomyces sp. WP-1, an endophyte from Pinus dabeshanensis, and its antifungal activity against Fusarium oxysporum[1]. |
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| References | [1]. Peng C, et al. Fungichromin production by Streptomyces sp. WP-1, an endophyte from Pinus dabeshanensis, and its antifungal activity against Fusarium oxysporum. Appl Microbiol Biotechnol. 2020;104(24):10437-10449. |
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Chemical & Physical Properties
| Density | 1.196g/cm3 |
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| Boiling Point | 914ºC at 760 mmHg |
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| Molecular Formula | C35H58O12 |
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| Molecular Weight | 670.83 |
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| Flash Point | 278.4ºC |
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| Exact Mass | 670.39300 |
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| PSA | 228.60000 |
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| LogP | 0.85880 |
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| Index of Refraction | 1.545 |
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| InChIKey | AGJUUQSLGVCRQA-UHFFFAOYSA-N |
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| SMILES | CCCCCC(O)C1C(=O)OC(C)C(O)C=CC=CC=CC=CC=C(C)C(O)C(O)C(O)CC(O)CC(O)CC(O)CC(O)CC1O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- LT3850000
- CHEMICAL NAME :
- Fungichromin
- CAS REGISTRY NUMBER :
- 6834-98-6
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C35-H58-O12
- MOLECULAR WEIGHT :
- 670.93
- WISWESSER LINE NOTATION :
- T-28-OV RU TU VU A&U C&UTJ CYQ5 DQ FQ HQ JQ LQ NQ OQ PQ R1 E&Q F&1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1624 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 11,26,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 16400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 2,716,1954/1955
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Synonyms
| Pentamycin |
| S 232 |
| all-trans-3,5,7,9,11,13,14,15,26,27-Decahydroxy-2,1'-hydroxyhexyl-16-methyl-octacosa-16,18,20,22,24-pentaen-saeure-1->27-lacton |
| 14-Hydroxyfilipin |
| Cogomycin |
| Antibiotic A-246 |
| Lagosin (antibiotic) |
| EINECS 229-913-4 |
| Lagosin |
| Fungichromin |
