CAS 84-17-3|Dienestrol
Introduction：Basic information about CAS 84-17-3|Dienestrol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dienestrol | ||
|---|---|---|---|
| CAS Number | 84-17-3 | Molecular Weight | 266.33400 |
| Density | 1.129 g/cm3 | Boiling Point | 395.4ºC at 760 mmHg |
| Molecular Formula | C18H18O2 | Melting Point | 229ºC |
| MSDS | / | Flash Point | 181.4ºC |
| Symbol | GHS08 | Signal Word | Danger |
Names
| Name | dienestrol |
|---|---|
| Synonym | More Synonyms |
Dienestrol BiologicalActivity
| Description | Dienestrol is a synthetic, non-steroidal estrogen, is an estrogen receptor agonist, for the treatment of menopausal and postmenopausal symptoms. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>Estrogen Receptor/ERRResearch Areas >>Endocrinology |
Chemical & Physical Properties
| Density | 1.129 g/cm3 |
|---|---|
| Boiling Point | 395.4ºC at 760 mmHg |
| Melting Point | 229ºC |
| Molecular Formula | C18H18O2 |
| Molecular Weight | 266.33400 |
| Flash Point | 181.4ºC |
| Exact Mass | 266.13100 |
| PSA | 40.46000 |
| LogP | 4.60460 |
| Index of Refraction | 1.4800 (estimate) |
| InChIKey | NFDFQCUYFHCNBW-UHFFFAOYSA-N |
| SMILES | CC=C(C(=CC)c1ccc(O)cc1)c1ccc(O)cc1 |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 40 ug/kg
- SEX/DURATION :
- female 3 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
- TYPE OF TEST :
- Unscheduled DNA synthesis
MUTATION DATA - TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TEST SYSTEM :
- Rodent - hamster Fibroblast
- DOSE/DURATION :
- 75 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 171,31,1986 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,278,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83633 No. of Facilities: 124 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 2882 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83633 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 166 (estimated) No. of Female Employees: 105 (estimated)
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TEST SYSTEM :
- Rodent - hamster Fibroblast
- DOSE/DURATION :
- 75 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 171,31,1986 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,278,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83633 No. of Facilities: 124 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 2882 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83633 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 166 (estimated) No. of Female Employees: 105 (estimated)
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H350-H361 |
| Precautionary Statements | P201-P280-P308 + P313 |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R40 |
| Safety Phrases | S22;S24/25 |
| RIDADR | 2811.0 |
| WGK Germany | 3 |
| RTECS | SL0580000 |
| Hazard Class | 6.1 |
Articles4
More Articles| Graphene oxide-based microspheres for the dispersive solid-phase extraction of non-steroidal estrogens from water samples. J. Chromatogr. A. 1368 , 18-25, (2014) A modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method based on the dispersive solid-phase extraction (dSPE) combined with high performance liquid chromatography (HPLC) was develo... | |
| Packed-fiber solid-phase extraction coupled with high performance liquid chromatography–tandem mass spectrometry for determination of diethylstilbestrol, hexestrol, and dienestrol residues in milk products J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 957 , 7-13, (2014) • A method based on packed-fiber solid-phase extraction (PF SPE) has been established for the determination of three estrogenic stilbenes in dairy products. • Samples were pretreated with PF SPE using... | |
| Quantitative determination of 26 steroids in eggs from various species using liquid chromatography-triple quadrupole-mass spectrometry. J. Chromatogr. A. 1356 , 54-63, (2014) A method for analyzing 26 types of steroids in egg matrix was developed. The method used liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) in electrospray ionization mode (ESI). T... |
Synonyms
| Retalon |
| Oestrora |
| Dinestrol |
| MFCD00050983 |
| Isodienoestrol |
| Agaldog |
| Sexadien |
| Estroral |
| Dienoestrol |
| EINECS 201-519-7 |
| Dinovex |
| Teserene |
| Restrol |
| 2,4-Hexadiene, 3,4-bis(4-hydroxyphenyl)- |
