Introduction：Basic information about CAS 21738-42-1|Oxamniquine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Oxamniquine |
|---|
| CAS Number | 21738-42-1 | Molecular Weight | 279.33500 |
|---|
| Density | 1.174g/cm3 | Boiling Point | 443.6ºC at 760mmHg |
|---|
| Molecular Formula | C14H21N3O3 | Melting Point | 147-149ºC |
|---|
| MSDS | / | Flash Point | 222.1ºC |
|---|
Names
| Name | {2-[(isopropylamino)methyl]-7-nitro-1,2,3,4-tetrahydroquinolin-6-yl}methanol |
|---|
| Synonym | More Synonyms |
|---|
Oxamniquine BiologicalActivity
| Description | Oxamniquine is a potent agent for the treatment of schistosomiasis. |
|---|
| Related Catalog | Research Areas >>Infection |
|---|
| Target | Parasite[1] |
|---|
| In Vitro | Oxamniquine is a potent agent for the treatment of schistosomiasis[1]. |
|---|
| In Vivo | Oxamniquine (500 mg/kg) alone or Oxamniquine (250 mg/kg) in combination with praziquantel reduces the mortality of infected snails compared to the control group[1]. |
|---|
| References | [1]. Mattos AC, et al. Evaluation of the effect of oxamniquine, praziquantel and a combination of both drugs on the intramolluscan phase of Schistosoma mansoni. Acta Trop. 2007 May;102(2):84-91. |
|---|
Chemical & Physical Properties
| Density | 1.174g/cm3 |
|---|
| Boiling Point | 443.6ºC at 760mmHg |
|---|
| Melting Point | 147-149ºC |
|---|
| Molecular Formula | C14H21N3O3 |
|---|
| Molecular Weight | 279.33500 |
|---|
| Flash Point | 222.1ºC |
|---|
| Exact Mass | 279.15800 |
|---|
| PSA | 90.11000 |
|---|
| LogP | 2.86390 |
|---|
| Vapour Pressure | 1.19E-08mmHg at 25°C |
|---|
| Index of Refraction | 1.56 |
|---|
| InChIKey | XCGYUJZMCCFSRP-UHFFFAOYSA-N |
|---|
| SMILES | CC(C)NCC1CCc2cc(CO)c([N+](=O)[O-])cc2N1 |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- VC0340000
- CHEMICAL NAME :
- 6-Quinolinemethanol, 1,2,3,4-tetrahydro-2-((isopropylamino)methyl)-7-nitro -
- CAS REGISTRY NUMBER :
- 21738-42-1
- BEILSTEIN REFERENCE NO. :
- 0485597
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 21
- MOLECULAR FORMULA :
- C14-H21-N3-O3
- MOLECULAR WEIGHT :
- 279.38
- WISWESSER LINE NOTATION :
- T66 BMT&J C1MY1&1 H1Q INW
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Liver - fatty liver degeneration
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Liver - fatty liver degeneration
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Liver - fatty liver degeneration
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 650 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 950 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
MUTATION DATA - TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 1 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 157,1,1985
|
Safety Information
Customs
| HS Code | 2933499090 |
|---|
| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|---|
Synonyms
| Oxamniquina |
| Mansil |
| oxamniquine |
| [7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,4-tetrahydroquinolin-6-yl]methanol |
| UK-4271 |
| dl-6-hydroxymethyl-2-isopropylaminomethyl-7-nitro-1,2,3,4-tetrahydroquinoline |
| Oxamniquinum |
| Vansil |
| Oxaminiquine |
