Introduction：Basic information about CAS 51543-39-6|Esflurbiprofen, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Esflurbiprofen |
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| CAS Number | 51543-39-6 | Molecular Weight | 244.261 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 376.2±30.0 °C at 760 mmHg |
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| Molecular Formula | C15H13FO2 | Melting Point | 109-110ºC(lit.) |
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| MSDS | / | Flash Point | 181.3±24.6 °C |
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Names
| Name | (S)-flurbiprofen |
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| Synonym | More Synonyms |
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Esflurbiprofen BiologicalActivity
| Description | (S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC50 values of 0.48 μM and 0.47 μM for COX-1 and COX-2, respectively[1]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COXSignaling Pathways >>Immunology/Inflammation >>PGE synthase |
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| Target | COX-1:0.48 μM (IC50) COX-2:0.47 μM (IC50) |
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| In Vitro | (S)-Flurbiprofen (10–7 M) results in a total suppression of basal and stimulated PGE2 release in rat skin[2]. |
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| References | [1]. A Carabaza, et al. Stereoselective Inhibition of Inducible Cyclooxygenase by Chiral Nonsteroidal Antiinflammatory Drugs. J Clin Pharmacol. 1996 Jun;36(6):505-12. [2]. B Averbeck, et al. Inflammatory Mediators Do Not Stimulate CGRP Release if Prostaglandin Synthesis Is Blocked by S(+)-flurbiprofen in Isolated Rat Skin. Inflamm Res. 2003 Dec;52(12):519-23. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 376.2±30.0 °C at 760 mmHg |
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| Melting Point | 109-110ºC(lit.) |
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| Molecular Formula | C15H13FO2 |
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| Molecular Weight | 244.261 |
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| Flash Point | 181.3±24.6 °C |
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| Exact Mass | 244.089951 |
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| PSA | 37.30000 |
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| LogP | 4.11 |
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| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
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| Index of Refraction | 1.568 |
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| InChIKey | SYTBZMRGLBWNTM-JTQLQIEISA-N |
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| SMILES | CC(C(=O)O)c1ccc(-c2ccccc2)c(F)c1 |
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Safety Information
| Hazard Codes | T |
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| Risk Phrases | R25 |
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| Safety Phrases | 36/37/39-45 |
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| RIDADR | UN 2811 6.1/PG 3 |
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| WGK Germany | 3 |
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Synonyms
| [1,1'-biphenyl]-4-acetic acid, 2-fluoro-a-methyl- |
| 2-Fluoro-α-methyl[1,1'-biphenyl]-4-acetic acid |
| 2-FLUORO-α-METHYL-4-BIPHENYLACETIC ACID |
| 2-(2-Fluoro-4-biphenylyl)propanoic acid |
| Froben |
| Anside |
| EINECS 257-263-1 |
| d-Flurbiprofen |
| [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl- |
| Stayban |
| Esflurbiprofen |
| MFCD00866152 |
| (S)-Flurbiprofen |
| 2-(2-fluorobiphenyl-4-yl)propanoic acid |
| Ocufen |
| Ansaid |
| (±)-Flurbiprofen |
| 2-(2-fluoro-4-biphenylyl)propionic acid |
| Zepolas |
| Adfeed |
| rac-Flurbiprofen |
| tarenflurbil |
| Flurbiprofen |
