Introduction：Basic information about CAS 111821-58-0|(S)-(-)-HA-966, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (S)-(-)-HA-966 |
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| CAS Number | 111821-58-0 | Molecular Weight | 116.11900 |
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| Density | 1.436 g/cm3 | Boiling Point | 258.6ºC at 760 mmHg |
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| Molecular Formula | C4H8N2O2 | Melting Point | / |
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| MSDS | / | Flash Point | 110.2ºC |
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Names
| Name | (s)-(-)-3-amino-1-hydroxypyrrolidin-2-one |
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| Synonym | More Synonyms |
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(S)-(-)-HA-966 BiologicalActivity
| Description | (S)-(-)-HA 966 ((-)-HA 966), a γ-Hydroxybutyrate-like agent, is weakly active as an NMDA-receptor antagonist. (S)-(-)-HA 966 possesses muscle relaxant action and prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear[1][2]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR |
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| In Vitro | On cultured cortical neurones (+)-HA-966 inhibits glycine-potentiated NMDA responses with an IC50=13 μM compared with (-)-HA-966 (IC50=708 μM)[2]. |
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| In Vivo | (S)-(-)-HA 966 ((-)-HA 966; 3 and 5 mg/kg; i.p.) prevents restraint stress-induced dopamine utilization in both the medial prefrontal cortex and nucleus accumbens. (S)-(-)-HA 966 suppresses fear-induced behaviors: immobility and defecation[1]. (S)-(-)-HA 966 (3 mg/kg; i.p.) prevents locomotor sensitization without altering the acute motoric response elicited by cocaine[1]. (S)-(-)-HA 966 (5 mg/kg; i.p.) blocks acute cocaine-induced locomotion but resulted in sedation[1]. |
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| References | [1]. B A Morrow, et al. (S)-(-)-HA-966, a gamma-hydroxybutyrate-like agent, prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear and cocaine sensitization. J Pharmacol Exp Ther. 1997 Nov;283(2):712-21. [2]. L Singh, et al. Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative. Proc Natl Acad Sci U S A. 1990 Jan;87(1):347-51. |
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Chemical & Physical Properties
| Density | 1.436 g/cm3 |
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| Boiling Point | 258.6ºC at 760 mmHg |
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| Molecular Formula | C4H8N2O2 |
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| Molecular Weight | 116.11900 |
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| Flash Point | 110.2ºC |
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| Exact Mass | 116.05900 |
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| PSA | 66.56000 |
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| InChIKey | HCKUBNLZMKAEIN-VKHMYHEASA-N |
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| SMILES | NC1CCN(O)C1=O |
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Synonyms
| l-a-amino-e-n-benzyl-caprolactam |
| 7-Nitroindazole |
