Introduction：Basic information about CAS 112226-61-6|HALOFENOZIDE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Halofenozide (RH-0345) is an ecdysteroid agonist. RH-0345 belongs to a new group of insect growth regulators (IGRs) with a benzoylhydrazine structure that mimic the action of the natural insect molting hormone 20-hydroxyecdysone[1].
Related Catalog
Research Areas >>OthersSignaling Pathways >>Others >>Others
In Vitro
Halofenozide (RH-0345) reduces both growth and development of oocytes in vitro[1]. Cell Viability Assay[2] Cell Line: Cultured ovaries were dissected from female adult beetles of mealworm, Tenebrio molitor (T. molitor) Concentration: 1 μM and 10 μM Incubation Time: 4 days Result: Did not cause a significant effect on ecdysteroid amounts in the culture medium using ovaries from 0- and 2-day-old females at 10 μM. Caused a small significant increase of the amounts of ovarian ecdysteroids in the culture medium at 1 μM in the culture medium and with 2-day-old ovaries.
In Vivo
After topical application of Halofenozide (RH-0345; 5 and 10 μg) on adult females, the highest dose (10 μg) reduces significantly the reproductive parameters scored: namely the oviposition period, the fecundity and the egg viability[1]. Halofenozide at the two doses tested (5 and 10 μg) causes smaller eggs with a decrease in length, width and volume[1]. Animal Model: Newly emerged (0-day-old) adult females of T. molitor [1] Dosage: 5 and 10 μg Administration: Topically applied Result: Caused smaller eggs with a decrease in length, width and volume at the two doses tested (5 and 10 μg) .
References
[1]. Faïza Taïbi, et al. Effect of ecdysone agonist RH-0345 on reproduction of mealworm, Tenebrio molitor. Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jul;135C(3):257-67.
Chemical & Physical Properties
Density
1.205g/cm3
Melting Point
198.0-199.0°
Molecular Formula
C18H19ClN2O2
Molecular Weight
330.81
Exact Mass
330.11400
PSA
49.41000
LogP
4.31660
Index of Refraction
1.584
InChIKey
CNKHSLKYRMDDNQ-UHFFFAOYSA-N
SMILES
CC(C)(C)N(NC(=O)c1ccc(Cl)cc1)C(=O)c1ccccc1
Safety Information
Symbol
GHS07, GHS09
Signal Word
Warning
Hazard Statements
H317-H411
Precautionary Statements
P273-P280
Hazard Codes
Xi,N
Risk Phrases
43-51/53
Safety Phrases
24-37-61
RIDADR
UN 3077
RTECS
DG4976795
Packaging Group
III
Hazard Class
9
Articles1
More Articles
Two Leptinotarsa uridine diphosphate N-acetylglucosamine pyrophosphorylases are specialized for chitin synthesis in larval epidermal cuticle and midgut peritrophic matrix.
Insect Biochem. Mol. Biol. 68 , 12-Jan, (2016)
Uridine diphosphate-N-acetylglucosamine-pyrophosphorylase (UAP) is involved in the biosynthesis of chitin, an essential component of the epidermal cuticle and midgut peritrophic matrix (PM) in insects...
