Introduction：Basic information about CAS 992-21-2|Lymecycline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Lymecycline |
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| CAS Number | 992-21-2 | Molecular Weight | 602.63 |
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| Density | 1.53 | Boiling Point | 840.5ºC at 760 mmHg |
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| Molecular Formula | C29H38N4O10 | Melting Point | 192.5°C |
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| MSDS | / | Flash Point | 462.1ºC |
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Names
| Name | lymecycline |
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| Synonym | More Synonyms |
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Lymecycline BiologicalActivity
| Description | Lymecycline is a tetracycline derivative, with broad-spectrum antibacterial activity and also has anti-inflammatory property. |
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| Related Catalog | Research Areas >>InfectionResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Anti-infection >>Bacterial |
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| Target | Bacterial[1] |
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| In Vitro | Lymecycline is a tetracycline derivative, with broad-spectrum antibacterial activity interfering with prokaryotic protein synthesis at the ribosome level. Lymecycline also has anti-inflammatory property[1]. |
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| References | [1]. Rempe S, et al. Tetracyclines and pulmonary inflammation. Endocr Metab Immune Disord Drug Targets. 2007 Dec;7(4):232-6. |
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Chemical & Physical Properties
| Density | 1.53 |
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| Boiling Point | 840.5ºC at 760 mmHg |
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| Melting Point | 192.5°C |
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| Molecular Formula | C29H38N4O10 |
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| Molecular Weight | 602.63 |
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| Flash Point | 462.1ºC |
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| Exact Mass | 602.25900 |
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| PSA | 242.98000 |
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| LogP | 1.02790 |
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| Index of Refraction | 1.693 |
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| Water Solubility | Very soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- OL5615000
- CHEMICAL NAME :
- Lysine, N(sup 6)-((4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro -3,6,10,12,12a- pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxa mido)methyl)-, (+)-
- CAS REGISTRY NUMBER :
- 992-21-2
- LAST UPDATED :
- 199201
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C29-H38-N4-O10
- MOLECULAR WEIGHT :
- 602.71
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 181 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,333,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 253 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,106,1964
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Synonyms
| limecycline |
| [(1r,7ar)-1-hydroxy-2,3,5,7a-tetrahydro-1h-pyrrolizin-7-yl]methyl(2r,3s)-2,3-dihydroxy-2-isopropylbutanoate |
| 2,3-Dihydroxy-2-(1-methylethyl)-butanoic acid (2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl) methyl ester |
| lycopsamine |
| (+)-Indicine |
