CAS 90429-66-6|Tempol-d17,15N
Introduction：Basic information about CAS 90429-66-6|Tempol-d17,15N, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tempol-d17,15N | ||
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| CAS Number | 90429-66-6 | Molecular Weight | 190.34300 |
| Density | / | Boiling Point | / |
| Molecular Formula | C9HD17NO2 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (d17, 15n) |
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Tempol-d17,15N BiologicalActivity
| Description | Tempol-d17,15N is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic drug that efficiently neutralizes reactive oxygen species (ROS)[2][3]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Autophagy >>Autophagy |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Vilar-Pereira G, et al. Resveratrol Reverses Functional Chagas Heart Disease in Mice. PLoS Pathog. 2016 Oct 27;12(10):e1005947. [3]. Chatterjee PK, et al. Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney Int. 2000 Aug58(2):658-73. |
Chemical & Physical Properties
| Molecular Formula | C9HD17NO2 |
|---|---|
| Molecular Weight | 190.34300 |
| Exact Mass | 190.23700 |
| PSA | 23.47000 |
| LogP | 1.28370 |
