CAS 210108-89-7|2,5,7,14-Tetraacetoxy-3-benzoyloxy-8,15-dihydroxy-9-nicotinoyloxyjatropha-6(1

Introduction：Basic information about CAS 210108-89-7|2,5,7,14-Tetraacetoxy-3-benzoyloxy-8,15-dihydroxy-9-nicotinoyloxyjatropha-6(1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	2,5,7,14-Tetraacetoxy-3-benzoyloxy-8,15-dihydroxy-9-nicotinoyloxyjatropha-6(17),11E-diene
CAS Number	210108-89-7	Molecular Weight	779.826
Density	1.3±0.1 g/cm3	Boiling Point	797.3±60.0 °C at 760 mmHg
Molecular Formula	C₄₁H₄₉NO₁₄	Melting Point	/
MSDS	/	Flash Point	436.0±32.9 °C

Names

Name	(Z)-3-(benzoyloxy)-7,13a-dihydroxy-2,9,9,12-tetramethyl-5-methylene-8-(nicotinoyloxy)-2,3,3a,4,5,6,7,8,9,12,13,13a-dodecahydro-1H-cyclopenta[12]annulene-2,4,6,13-tetrayl tetraacetate
Synonym	More Synonyms

BiologicalActivity

Description	Jatrophane 5 is a natural product of Jatropha carcas L. Jatrophane 5 has powerful inhibition of P-gp, higher than R(+)-verapamil (HY-14275) and Tariquidar (HY-10550) in colorectal multi-drug resistant cells (DLD1-TxR)[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Membrane Transporter/Ion Channel >>P-glycoprotein
References	[1]. Jadranin M, et al. Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines. Phytochemistry. 2013;86:208-217.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	797.3±60.0 °C at 760 mmHg
Molecular Formula	C₄₁H₄₉NO₁₄
Molecular Weight	779.826
Flash Point	436.0±32.9 °C
Exact Mass	779.315308
PSA	211.15000
LogP	5.46
Vapour Pressure	0.0±2.9 mmHg at 25°C
Index of Refraction	1.578
InChIKey	GLYDSECXZWCLMS-UHFFFAOYSA-N
SMILES	C=C1C(OC(C)=O)C(O)C(OC(=O)c2cccnc2)C(C)(C)C=CC(C)C(OC(C)=O)C2(O)CC(C)(OC(C)=O)C(OC(=O)c3ccccc3)C2C1OC(C)=O

Safety Information

Hazard Codes	Xi

Synonyms

(2R,3R,3aS,4R,6R,7S,8S,10Z,12S,13S,13aR)-2,4,6,13-Tetraacetoxy-3-(benzoyloxy)-7,13a-dihydroxy-2,9,9,12-tetramethyl-5-methylene-2,3,3a,4,5,6,7,8,9,12,13,13a-dodecahydro-1H-cyclopenta[12]annulen-8-yl nicotinate

3-Pyridinecarboxylic acid, (2R,3R,3aS,4R,6R,7S,8S,10Z,12S,13S,13aR)-2,4,6,13-tetrakis(acetyloxy)-3-(benzoyloxy)-2,3,3a,4,5,6,7,8,9,12,13,13a-dodecahydro-7,13a-dihydroxy-2,9,9,12-tetramethyl-5-methylene-1H-cyclopentacyclododecen-8-yl ester

(2R,3R,3aS,4R,6S,7S,8S,10E,12R,13R,13aR)-2,4,6,13-Tetraacetoxy-3-(benzoyloxy)-7,13a-dihydroxy-2,9,9,12-tetramethyl-5-methylene-2,3,3a,4,5,6,7,8,9,12,13,13a-dodecahydro-1H-cyclopenta[12]annulen-8-yl nicotinate

3-Pyridinecarboxylic acid, (2R,3R,3aS,4R,6S,7S,8S,10E,12R,13R,13aR)-2,4,6,13-tetrakis(acetyloxy)-3-(benzoyloxy)-2,3,3a,4,5,6,7,8,9,12,13,13a-dodecahydro-7,13a-dihydroxy-2,9,9,12-tetramethyl-5-methylene-1H-cyclopentacyclododecen-8-yl ester

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