Introduction：Basic information about CAS 856866-72-3|Tedizolid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tedizolid |
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| CAS Number | 856866-72-3 | Molecular Weight | 370.338 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 614.5±65.0 °C at 760 mmHg |
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| Molecular Formula | C17H15FN6O3 | Melting Point | / |
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| MSDS | / | Flash Point | 325.4±34.3 °C |
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Names
| Name | tedizolid |
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| Synonym | More Synonyms |
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Tedizolid BiologicalActivity
| Description | Tedizolid is a novel oxazolidinone, acting through inhibition of bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA) of the 50S subunit of the ribosome. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection |
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| In Vitro | Tedizolid (0.25 μg/mL) inhibits all 28 clinical isolates of PRSP, and is 4-fold more potent than linezolid against PRSP[1]. |
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| In Vivo | For mice infected with PSSP type III, the 100% survival rate is achieved with tedizolid phosphate at a minimum total daily dose of 10 mg/kg. Lungs of infected mice treated with tedizolid phosphate show less severe inflammation and edema, as indicated by the mean scores for inflammation and edema[1]. |
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| Animal Admin | To induce a systemic S. pneumoniae infection, male ICR mice (weight, 18 to 20 g) are inoculated intraperitoneally with 1 of 4 PRSP isolates (DR9, DR10, DR11, or DR14) suspended in 10% mucin. The suspension contained sufficient bacteria to kill 100% of untreated control mice. At 1 h postinfection, mice receives a single dose of either tedizolid phosphate or linezolid, and survival is assessed daily for 7 days postinfection. Treatments are delivered both orally and intravenously at each of four doses (40 mg/kg of body weight, 13.33 mg/kg, 4.44 mg/kg, and 1.48 mg/kg), with 8 mice per group defined by dose, delivery method, and infecting strain. The 50% effective dose (ED50), i.e., the dose allowing survival of 50% of the infected mice, is calculated for each delivery route using probit analysis. |
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| References | [1]. Choi S, et al. Activity of Tedizolid Phosphate (TR-701) in Murine Models of Infection with Penicillin-resistant and Penicillin-sensitive Streptococcus pneumoniae. Antimicrob Agents Chemother. 2012 Jun 19. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 614.5±65.0 °C at 760 mmHg |
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| Molecular Formula | C17H15FN6O3 |
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| Molecular Weight | 370.338 |
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| Flash Point | 325.4±34.3 °C |
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| Exact Mass | 370.118958 |
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| PSA | 106.26000 |
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| LogP | 1.56 |
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| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
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| Index of Refraction | 1.725 |
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| InChIKey | XFALPSLJIHVRKE-GFCCVEGCSA-N |
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| SMILES | Cn1nnc(-c2ccc(-c3ccc(N4CC(CO)OC4=O)cc3F)cn2)n1 |
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Safety Information
Synonyms
| (5R)-3-{3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl}-5-(hydroxymethyl)-1,3-oxazolidin-2-one |
| Torezolid |
| TR-701 |
| (5R)-3-[3-fluoro-4-[6-(2-methyltetrazol-5-yl)pyridin-3-yl]phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one |
| TR-700 |
| (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one |
| Tedizolid [USAN:INN] |
| 2-Oxazolidinone, 3-[3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-(hydroxymethyl)-, (5R)- |
| UNII:97HLQ82NGL |
| Tedizolid |
| (5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl]phenyl}-5-(hydroxymethyl)-2-oxazolidinone |
