Introduction：Basic information about CAS 113122-54-6|3-Deoxysappanone B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3-Deoxysappanone B |
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| CAS Number | 113122-54-6 | Molecular Weight | 286.279 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 587.4±50.0 °C at 760 mmHg |
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| Molecular Formula | C16H14O5 | Melting Point | / |
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| MSDS | / | Flash Point | 225.0±23.6 °C |
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Names
| Name | 3-(3,4-Dihydroxybenzyl)-7-hydroxy-2,3-dihydro-4H-chromen-4-one |
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| Synonym | More Synonyms |
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3-Deoxysappanone B BiologicalActivity
| Description | Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage[1]. |
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| Related Catalog | Signaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease |
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| References | [1]. Ke-Wu Zeng, et al. Deoxysappanone B, a homoisoflavone from the Chinese medicinal plant Caesalpinia sappan L., protects neurons from microglia-mediated inflammatory injuries via inhibition of IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Eur J Pharmacol. 2015 Feb 5;748:18-29. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 587.4±50.0 °C at 760 mmHg |
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| Molecular Formula | C16H14O5 |
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| Molecular Weight | 286.279 |
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| Flash Point | 225.0±23.6 °C |
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| Exact Mass | 286.084137 |
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| PSA | 86.99000 |
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| LogP | 2.61 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.684 |
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| InChIKey | KCUXSQJYIWEGRG-UHFFFAOYSA-N |
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| SMILES | O=C1c2ccc(O)cc2OCC1Cc1ccc(O)c(O)c1 |
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Safety Information
Synonyms
| 3-deoxysappanone B |
| 4H-1-Benzopyran-4-one, 3-[(3,4-dihydroxyphenyl)methyl]-2,3-dihydro-7-hydroxy- |
| 3-(3,4-Dihydroxybenzyl)-7-hydroxy-2,3-dihydro-4H-chromen-4-one |
