Introduction：Basic information about CAS 59729-37-2|Fexinidazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fexinidazole |
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| CAS Number | 59729-37-2 | Molecular Weight | 279.315 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 511.3±40.0 °C at 760 mmHg |
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| Molecular Formula | C12H13N3O3S | Melting Point | / |
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| MSDS | / | Flash Point | 263.0±27.3 °C |
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Names
| Name | 1-methyl-2-[(4-methylsulfanylphenoxy)methyl]-5-nitroimidazole |
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| Synonym | More Synonyms |
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Fexinidazole BiologicalActivity
| Description | Fexinidazole is a 5-nitroimidazole drug currently in clinical development for the treatment of human sleeping sickness (human African trypanosomiasis [HAT]), caused by infection with species of the protozoan parasite Trypanosoma brucei. Target: Antiparasiticin vivo: Fexinidazole shows dose-related efficacy in the T. b. rhodesiense (STIB900) acute mouse model at intraperitoneal (i.p.) doses of 20 to 50 mg/kg/day and oral (per os [p.o.]) doses of 25 to 100 mg/kg/day given on four consecutive days, with 100 mg/kg/day p.o. being 100% curative. Fexinidazole is shown to be effective in the GVR35 mouse model, which mimics the advanced and fatal stage of the disease, when parasites have disseminated into the brain. [1] |
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| Related Catalog | Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection |
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| References | [1]. Kaiser M, et al. Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness. Antimicrob Agents Chemother. 2011 Dec;55(12):5602-8. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 511.3±40.0 °C at 760 mmHg |
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| Molecular Formula | C12H13N3O3S |
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| Molecular Weight | 279.315 |
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| Flash Point | 263.0±27.3 °C |
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| Exact Mass | 279.067749 |
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| PSA | 98.17000 |
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| LogP | 2.28 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.629 |
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| InChIKey | MIWWSGDADVMLTG-UHFFFAOYSA-N |
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| SMILES | CSc1ccc(OCc2ncc([N+](=O)[O-])n2C)cc1 |
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| Storage condition | 2-8℃ |
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Safety Information
Customs
| HS Code | 2933290090 |
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| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1-Methyl-2-{[4-(methylsulfanyl)phenoxy]methyl}-5-nitro-1H-imidazole |
| 1-methyl-2-(4-methylthiophenyl-oxymethyl)-5-nitro-imidazole |
| 1-Methyl-2-((4-(methylthio)phenoxy)methyl)-5-nitro-1H-imidazole |
| 1-methyl-2-(4-methylsulfanyl-phenoxymethyl)-5-nitro-1H-imidazole |
| Fexinidazol |
| Fexinidazole |
| Fexinidazolum |
| 1H-Imidazole, 1-methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro- |
| 1-Methyl-2-((p-(methylthio)phenoxy)methyl)-5-nitroimidazole |
| HOE-239 |
