Introduction：Basic information about CAS 111393-84-1|Amitivir, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Amitivir |
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| CAS Number | 111393-84-1 | Molecular Weight | 126.14000 |
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| Density | 1.613g/cm3 | Boiling Point | 236.3ºC at 760mmHg |
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| Molecular Formula | C3H2N4S | Melting Point | / |
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| MSDS | / | Flash Point | 96.7ºC |
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Names
| Name | 1,3,4-Thiadiazol-2-ylcyanamide |
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| Synonym | More Synonyms |
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Amitivir BiologicalActivity
| Description | Amitivir (LY 217896), a thiadiazole derivative, possesses broad antiviral activity against orthomyxo- and paramyxoviruses. Amitivir is effective against influenza A and B viruses[1][2]. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>Influenza VirusResearch Areas >>Infection |
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| In Vitro | The mean 50% inhibitory concentration of Amitivir inhibits six strains of type A influenza (A/Russia, A/Brazil/11/78, A/Ann Arbor/1/57, A/Port Chalmers/1/73, A/Hong Kong/8/68 and A/X-15) ranged from 0.37 to 1.19 μg/ml. The mean 50% inhibitory concentration of Amitivir inhibits four strains of influenza B virus (B/Maryland/11/59, B/GreatLakes/1739/54, B/Singapore/3/64, B/Lee/40) ranged from 0.75 to 1.54 μg/ml[2]. |
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| In Vivo | Amitivir (LY 217896) (9 mg/m2 of body surface area per day) administered in the diet, in the drinking water, by oral gavage, by intraperitoneal injection, or by aerosolization was well tolerated and protected CD-1 mice infected with a lethal dose of influenza A or B virus[2]. |
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| References | [1]. Hayden FG, et al. Oral LY217896 for prevention of experimental influenza A virus infection and illness in humans. Antimicrob Agents Chemother. 1994;38(5):1178-1181. [2]. Colacino JM, et al. Evaluation of the anti-influenza virus activities of 1,3,4-thiadiazol-2-ylcyanamide (LY217896) and its sodium salt. Antimicrob Agents Chemother. 1990;34(11):2156-2163. |
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Chemical & Physical Properties
| Density | 1.613g/cm3 |
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| Boiling Point | 236.3ºC at 760mmHg |
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| Molecular Formula | C3H2N4S |
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| Molecular Weight | 126.14000 |
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| Flash Point | 96.7ºC |
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| Exact Mass | 126.00000 |
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| PSA | 93.07000 |
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| Vapour Pressure | 0.0477mmHg at 25°C |
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| Index of Refraction | 1.703 |
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| InChIKey | YUCHAYRHHXJNQK-UHFFFAOYSA-N |
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| SMILES | N#CNc1nncs1 |
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Synonyms
| Amitivir (USAN/INN) |
| Amitivir |
| UNII-R4KR9A9165 |
