Introduction：Basic information about CAS 1430213-30-1|ML216, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ML216 |
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| CAS Number | 1430213-30-1 | Molecular Weight | 383.323 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C15H9F4N5OS | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 1-[4-Fluoro-3-(trifluoromethyl)phenyl]-3-[5-(4-pyridinyl)-1,3,4-t hiadiazol-2-yl]ure |
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| Synonym | More Synonyms |
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ML216 BiologicalActivity
| Description | ML216(CID-49852229) is a potent inhibitor of the DNA unwinding activity of BLM helicase; showing similar IC50s of 3.0 and 0.97 μM for full length BLM and BLM636–1298 respectively.IC50 value: 3.0/0.97 uM(Full length/636–1298 BLM)Target: BLM helicase inhibitorML216 shows cell-based activity, and can induce sister chromatid exchanges, enhance to the toxicity of aphidicolin and exert anti-proliferative activity in cells expressing BLM, but not in those lacking BLM. |
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| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisResearch Areas >>Cancer |
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| References | [1]. Nguyen GH, et al. A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. Chem Biol. 2013 Jan 24;20(1):55-62. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Molecular Formula | C15H9F4N5OS |
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| Molecular Weight | 383.323 |
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| Exact Mass | 383.046387 |
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| PSA | 114.76000 |
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| LogP | 4.11 |
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| Index of Refraction | 1.641 |
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| InChIKey | WMCOYUSJXXCHFH-UHFFFAOYSA-N |
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| SMILES | O=C(Nc1ccc(F)c(C(F)(F)F)c1)Nc1nnc(-c2ccncc2)s1 |
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| Storage condition | 2-8℃ |
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Synonyms
| Urea, N-[4-fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]- |
| 1-[4-Fluoro-3-(trifluoromethyl)phenyl]-3-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]urea |
| ML216 |
