Introduction：Basic information about CAS 120012-04-6|Dihydro Donepezil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dihydro Donepezil |
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| CAS Number | 120012-04-6 | Molecular Weight | 381.50800 |
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| Density | / | Boiling Point | 520.367ºC at 760 mmHg |
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| Molecular Formula | C24H31NO3 | Melting Point | / |
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| MSDS | / | Flash Point | 268.509ºC |
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Names
| Name | 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-ol |
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| Synonym | More Synonyms |
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Dihydro Donepezil BiologicalActivity
| Description | Dihydro Donepezil (Dihydro E2020) is a metabolite of Donepezil. Donepezil is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bAChE and hAChE, respectively[1]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>AChE |
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| References | [1]. Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13. |
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Chemical & Physical Properties
| Boiling Point | 520.367ºC at 760 mmHg |
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| Molecular Formula | C24H31NO3 |
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| Molecular Weight | 381.50800 |
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| Flash Point | 268.509ºC |
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| Exact Mass | 381.23000 |
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| PSA | 41.93000 |
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| LogP | 4.14970 |
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| Vapour Pressure | 0mmHg at 25°C |
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| Index of Refraction | 1.587 |
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| InChIKey | UGTUAFCYSWJIHS-UHFFFAOYSA-N |
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| SMILES | COc1cc2c(cc1OC)C(O)C(CC1CCN(Cc3ccccc3)CC1)C2 |
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Synonyms
| IND032 |
| Dihydro Donepezil |
| Donepezil Impurity 5 |
