Introduction：Basic information about CAS 197431-02-0|Debutyldronedarone hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Debutyldronedarone hydrochloride |
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| CAS Number | 197431-02-0 | Molecular Weight | 537.11100 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C27H37ClN2O5S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Desbutyl Dronedarone Hydrochloride |
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| Synonym | More Synonyms |
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Debutyldronedarone hydrochloride BiologicalActivity
| Description | Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Thyroid Hormone Receptor |
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| Target | TRα1/TRβ1[1] |
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| References | [1]. Van Beeren HC, et al. Dronerarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence. Endocrinology. 2003 Feb;144(2):552-8. |
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Chemical & Physical Properties
| Molecular Formula | C27H37ClN2O5S |
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| Molecular Weight | 537.11100 |
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| Exact Mass | 536.21100 |
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| PSA | 106.02000 |
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| LogP | 7.88320 |
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| InChIKey | ZDXBTJLIQYUYSZ-UHFFFAOYSA-N |
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| SMILES | CCCCNCCCOc1ccc(C(=O)c2c(CCCC)oc3ccc(NS(C)(=O)=O)cc23)cc1.Cl |
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Safety Information
Synonyms
| N-[2-butyl-3-[4-[3-(butylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide,hydrochloride |
| Dronedarone Impurity 6 |
