Introduction：Basic information about CAS 142948-19-4|Scyllatoxin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Scyllatoxin |
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| CAS Number | 142948-19-4 | Molecular Weight | 3429.18000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C142H243N45O39S7 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | leiurotoxin i |
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| Synonym | More Synonyms |
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Scyllatoxin BiologicalActivity
| Description | Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus). Scyllatoxin is a blocker of small-conductance KCa (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo[1]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
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| In Vitro | For scyllatoxin, the Arg6 and Arg13 are essential for binding to the Ca2+-activated K+ channel protein and for the functional effect of the toxin[1]. For scyllatoxin, His31 is important for the binding activity of the toxin and for the induction of contractions on taenia coli[1]. |
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| In Vivo | Scyllatoxin (2 μM) increases basal Epi release, the nerve stimulation-induced Epi release and the exogenous acetylcholine (Ach)-induced catecholamine release by microdialysis technique to the left adrenal medulla of anesthetized adult male Wistar rats[2]. |
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| References | [1]. Auguste P, et al. Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure-function relationships and brain localization of the binding sites. Biochemistry. 1992 Jan 28;31(3):648-54. [2]. Akiyama T, et al. Role of Ca2+-activated K+ channels in catecholamine release from in vivo rat adrenal medulla. Neurochem Int. 2010 Jan;56(2):263-9. |
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Chemical & Physical Properties
| Molecular Formula | C142H243N45O39S7 |
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| Molecular Weight | 3429.18000 |
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| Exact Mass | 3426.65000 |
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| PSA | 1631.99000 |
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| LogP | 4.11960 |
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| InChIKey | MXWDLLUGULWYIQ-BFRWRHKQSA-N |
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| SMILES | CCC(C)C(NC(=O)C(CS)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(CCCNC(=N)N)NC(=O)C(CS)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCC(N)=O)NC(=O)C(CS)NC(=O)C(CCSC)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CC(N)=O)NC(=O)C(CS)NC(=O)C(Cc1ccccc1)NC(=O)C(C)N)C(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CS)C(=O)NC(CCC(=O)O)C(=O)NC(CS)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]cn1)C(N)=O)C(C)C |
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Synonyms
| Scyllatoxin,LeTx I |
| Leiurotoxin I Scyllatoxin,LeTx I |
| ALA-PHE-CYS-ASN-LEU-ARG-MET-CYS-GLN-LEU-SER-CYS-ARG-SER-LEU-GLY-LEU-LEU-GLY-LYS-CYS-ILE-GLY-ASP-LYS-CYS-GLU-CYS-VAL-LYS-HIS-NH2 |
| LETX I SCORPION TOXIN |
| LETX I |
| H-Ala-Phe-Cys-Asn-Leu-Arg-Met-Cys-Gln-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Asp-Lys-Cys-Glu-Cys-Val-Lys-His-NH2 |
| SCYLLATOXIN |
