CAS 158584-09-9|Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 trifluoroacetate salt
Introduction：Basic information about CAS 158584-09-9|Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 trifluoroacetate salt | ||
|---|---|---|---|
| CAS Number | 158584-09-9 | Molecular Weight | 1675.84 |
| Density | / | Boiling Point | / |
| Molecular Formula | C78H110N22O20 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | 7-Methoxycoumarin-4-acetyl-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-(2,4-dinitrophenyl)Lys amide |
|---|
BiologicalActivity
| Description | NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity[1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Metabolic Enzyme/Protease >>MMP |
| Target | MMP-3 MMP-10 |
| References | [1]. Giricz O, et al. Comparison of metalloproteinase protein and activity profiling. Anal Biochem. 2011 Feb 1;409(1):37-45. |
Chemical & Physical Properties
| Molecular Formula | C78H110N22O20 |
|---|---|
| Molecular Weight | 1675.84 |
| Exact Mass | 1674.83000 |
| PSA | 662.53000 |
| LogP | 8.39390 |
| InChIKey | TVZDWYYXHAIMCR-BKNSPTOHSA-N |
| SMILES | CCCC(NC(=O)C(CCC(=O)O)NC(=O)C(NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(CCCNC(=N)N)NC(=O)Cc1cc(=O)oc2cc(OC)ccc12)C(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCNc1ccc([N+](=O)[O-])cc1[N+](=O)[O-])C(N)=O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles1
More Articles| Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3). J. Biol. Chem. 269 , 20952-20957, (1994) Members of the matrix metalloproteinase (MMP) family have been implicated in disease states such as arthritis, periodontal disease, and tumor cell invasion and metastasis. Stromelysin 1 (MMP-3) has a ... |
