Introduction：Basic information about CAS 153088-73-4|Z-Asp-CH2-DCB, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Z-Asp-CH2-DCB |
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| CAS Number | 153088-73-4 | Molecular Weight | 454.258 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 674.2±55.0 °C at 760 mmHg |
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| Molecular Formula | C20H17Cl2NO7 | Melting Point | / |
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| MSDS | / | Flash Point | 361.6±31.5 °C |
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Names
| Name | z-asp-2,6-dichlorobenzoyloxymethylketone |
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| Synonym | More Synonyms |
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Z-Asp-CH2-DCB BiologicalActivity
| Description | Z-Asp-CH2-DCB is an irreversible broad spectrum caspase inhibitor. Z-Asp-CH2-DCB also inhibits proteases with caspase-like activity. Z-D-CH2-DCB blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in staphylococcal enterotoxin B (SEB)-stimulated peripheral blood mononuclear cells (PBMC), and reduces SEB-1-stimulated T-cell proliferation in a dose-dependent manner. Z-Asp-CH2-DCB prevents SU5416-induced septal cell apoptosis and emphysema development[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>CaspaseResearch Areas >>Inflammation/Immunology |
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| In Vitro | Z-Asp-CH2-DCB (10-100 μM) blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in SEB-stimulated (200 ng; 16 hours) PBMC in a dose-dependent manner. The production of the chemokines MCP-1, MIP-1α, and MIP-1β was also suppresses. The inhibitory effect of Z-Asp-CH2-DCB on TSST-1-activated PBMC is similar, reducing IL-1β, IL-6, TNF-α, IFN-γ, MCP-1, MIP-1α, and MIP-1β to 10, 36, 25, 10, 11, 25, and 30%, respectively, of levels in untreated cells[1]. Z-Asp-CH2-DCB (10-100 μM; 48 hours) inhibits T-cell proliferation in PBMC stimulated with 200 ng of SEB/ml [1]. Cell Viability Assay[1] Cell Line: Human peripheral blood mononuclear cells Concentration: 10, 50, 100 μM Incubation Time: 48 hours Result: Inhibited T-cell proliferation in PBMC stimulated with SEB. |
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| In Vivo | Z-Asp-CH2-DCB (1 mg; i.p.; every day for 3 weeks) prevents SU5416-induced septal cell apoptosis[1]. Animal Model: Male Sprague-Dawley rats (SU5416+ Z-Asp-CH2-DCB group)[1] Dosage: 1 mg Administration: Intraperitoneal injection; every day for 3 weeks Result: The caspase 3-like activity in SU5416-treated rat lungs is significantly higher, whereas lungs from rats treated with SU5416+Z-Asp-CH2-DCB showed no increase in apoptotic activity. |
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| References | [1]. Krakauer T, et al. Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation. Clin Diagn Lab Immunol. 2004 May;11(3):621-4. [2]. Kasahara Y, et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest. 2000 Dec;106(11):1311-9. [3]. Twumasi P, et al. Caspase inhibitors affect the kinetics and dimensions of tracheary elements in xylogenic Zinnia (Zinnia elegans) cell cultures. BMC Plant Biol. 2010 Aug 6;10:162. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 674.2±55.0 °C at 760 mmHg |
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| Molecular Formula | C20H17Cl2NO7 |
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| Molecular Weight | 454.258 |
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| Flash Point | 361.6±31.5 °C |
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| Exact Mass | 453.038208 |
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| PSA | 119.00000 |
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| LogP | 5.29 |
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| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
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| Index of Refraction | 1.594 |
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| InChIKey | FKJMFCOMZYPWCO-HNNXBMFYSA-N |
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| SMILES | O=C(O)CC(NC(=O)OCc1ccccc1)C(=O)COC(=O)c1c(Cl)cccc1Cl |
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Safety Information
Synonyms
| pase-1 inhibitor v |
| ice inhibitor vi |
| (3S)-3-{[(Benzyloxy)carbonyl]amino}-5-[(2,6-dichlorobenzoyl)oxy]-4-oxopentanoic acid |
| Benzoic acid, 2,6-dichloro-, (3S)-4-carboxy-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]butyl ester |
| pase-1 inhibitor iii |
| z-d-ch2-dcb |
| z-asp-ch2-dcb |
| ice inhibitor v |
