Introduction：Basic information about CAS 550-89-0|Oxychloroaphine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Oxychloroaphine |
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| CAS Number | 550-89-0 | Molecular Weight | 223.23000 |
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| Density | 1.371g/cm3 | Boiling Point | 526.1ºC at 760 mmHg |
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| Molecular Formula | C13H9N3O | Melting Point | 242ºC |
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| MSDS | / | Flash Point | 272ºC |
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Names
| Name | phenazine-1-carboxamide |
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| Synonym | More Synonyms |
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Oxychloroaphine BiologicalActivity
| Description | Oxychloroaphine could be isolated from the bacterium Pantoea agglomerans naturally present in soil. Oxychloroaphine has broad-spectrum antifungal activity. Oxychloroaphine has cytotoxicity in a dose-dependent manner and induces apoptosis. Oxychloroaphine can be used in research of cancer[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>Bcl-2 FamilySignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Epigenetics >>PARPResearch Areas >>InfectionSignaling Pathways >>Apoptosis >>MDM-2/p53Signaling Pathways >>Anti-infection >>FungalSignaling Pathways >>Apoptosis >>CaspaseSignaling Pathways >>Cell Cycle/DNA Damage >>PARP |
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| In Vitro | Oxychloroaphine (1-256 μM; 24 h) has cytotoxicity with IC50 values for A549, HeLa, and SW480 cancer cell lines between 32 and 40 μM[2]. Oxychloroaphine (1-150 μM; A549, HeLa, and SW480 cancer cell lines) causes cell membrane damage, leading to increase apoptosis and leakage of lactate dehydrogenase, and increases production of cytochrome c protein[2]. Oxychloroaphine (32 μM; A549 and SW480 cells) induces cycle arrest at G1 phase and induction of sub-G phase[2]. Oxychloroaphine (48 h; A549 cells) induces downregulation of antiapoptotic Bcl-2 protein and the activation of proapoptotic protein caspase-3 led to the cleavage of PARP[2]. Cell Viability Assay[2] Cell Line: A549, HeLa, and SW480 cancer cell lines Concentration: 1, 2, 4, 8, 16, 32, 64, 128, and 256 μM Incubation Time: 24 hours Result: Inhibited cell proliferative in a dose-dependent manner. |
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Chemical & Physical Properties
| Density | 1.371g/cm3 |
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| Boiling Point | 526.1ºC at 760 mmHg |
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| Melting Point | 242ºC |
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| Molecular Formula | C13H9N3O |
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| Molecular Weight | 223.23000 |
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| Flash Point | 272ºC |
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| Exact Mass | 223.07500 |
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| PSA | 68.87000 |
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| LogP | 2.58220 |
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| Index of Refraction | 1.76 |
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| InChIKey | KPZYYKDXZKFBQU-UHFFFAOYSA-N |
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| SMILES | NC(=O)c1cccc2nc3ccccc3nc12 |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| α-Amidophenazin |
| phenazine-1-carboxylic acid amide |
| PCN |
| 1-Carbamoyl-phenazin |
| Phenazine-1-carboxamide |
| Phenazin-1-carbamid |
