CAS 38537-24-5|(1,2,3,4,5,6,7,8-2H8)-9H-Carbazole

Introduction：Basic information about CAS 38537-24-5|(1,2,3,4,5,6,7,8-2H8)-9H-Carbazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name(1,2,3,4,5,6,7,8-2H8)-9H-Carbazole
CAS Number38537-24-5Molecular Weight175.256
Density1.2±0.1 g/cm3Boiling Point355.0±11.0 °C at 760 mmHg
Molecular FormulaC12HD8NMelting Point/
MSDS/Flash Point160.0±11.9 °C

Names

Namecarbazole-d8
SynonymMore Synonyms

(1,2,3,4,5,6,7,8-2H8)-9H-Carbazole BiologicalActivity

DescriptionCarbazole-d8 is the deuterium labeled Carbazole (HY-D0204). Carbazole is a tricyclic aromatic heterocyclic. Carbazole can form a new type of DNA minor groove complex to suppress the synthesis of new DNA or RNA[1][2].
Related CatalogSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisResearch Areas >>Others
In VitroStable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. F A Tanious, et al. A new type of DNA minor-groove complex: carbazole dication-DNA interactions. Biochemistry. 1997 Dec 9;36(49):15315-25.  

Chemical & Physical Properties

Density1.2±0.1 g/cm3
Boiling Point355.0±11.0 °C at 760 mmHg
Molecular FormulaC12HD8N
Molecular Weight175.256
Flash Point160.0±11.9 °C
Exact Mass175.123718
PSA15.79000
LogP3.72
Vapour Pressure0.0±0.8 mmHg at 25°C
Index of Refraction1.768
InChIKeyUJOBWOGCFQCDNV-PGRXLJNUSA-N
SMILESc1ccc2c(c1)[nH]c1ccccc12

Synonyms

(1,2,3,4,5,6,7,8-H)-9H-Carbazole
carbazole d8
9H-Carbazole-1,2,3,4,5,6,7,8-d
carbazole-d8,nh
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