Introduction：Basic information about CAS 847949-51-3|Gefitinib N-oxide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Gefitinib N-oxide |
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| CAS Number | 847949-51-3 | Molecular Weight | 462.90200 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C22H24ClFN4O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | N-(3-chloro-4-fluorophenyl)-[7-methoxy-6-(3-(4-(1-oxymorpholinyl))propoxy)-4-quinazolin]amine |
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| Synonym | More Synonyms |
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Gefitinib N-oxide BiologicalActivity
| Description | Gefitinib N-oxide is the N-oxide derivative of Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>JAK/STAT Signaling >>EGFRSignaling Pathways >>Protein Tyrosine Kinase/RTK >>EGFR |
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| Target | IC50: 37 nM (Tyr1173 site, in NR6wtEGFR cells), 37 nM (Tyr992 site, in NR6wtEGFR cells)[1] |
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| References | [1]. Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23. [2]. Moasser MM, et al. The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 2001 Oct 1;61(19):7184-8. |
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Chemical & Physical Properties
| Molecular Formula | C22H24ClFN4O4 |
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| Molecular Weight | 462.90200 |
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| Exact Mass | 462.14700 |
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| PSA | 94.93000 |
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| LogP | 4.32000 |
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Synonyms
| Gefitinib Morpholine N-oxide |
| Gefitinib N-Oxide |
| gefitinib N-oxide |
| Gefitinib Impurity 13 |
