CAS 1191888-51-3|Felbamate-d5
Introduction：Basic information about CAS 1191888-51-3|Felbamate-d5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Felbamate-d5 | ||
|---|---|---|---|
| CAS Number | 1191888-51-3 | Molecular Weight | 243.27100 |
| Density | / | Boiling Point | / |
| Molecular Formula | C11H9D5N2O4 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | Felbamate-d5 |
|---|
Felbamate-d5 BiologicalActivity
| Description | Felbamate-d5 is the deuterium labeled Felbamate[1]. Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA)[2][3]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Kuo CC, et al. Use-dependent inhibition of the N-methyl-D-aspartate currents by felbamate: a gating modifier with selective binding to the desensitized channels. Mol Pharmacol. 2004 Feb;65(2):370-80. [3]. Harty TP, et al. Felbamate block of recombinant N-methyl-D-aspartate receptors: selectivity for the NR2B subunit. Epilepsy Res. 2000 Mar;39(1):47-55. |
Chemical & Physical Properties
| Molecular Formula | C11H9D5N2O4 |
|---|---|
| Molecular Weight | 243.27100 |
| Exact Mass | 243.12700 |
| PSA | 104.64000 |
| LogP | 2.36140 |
