CAS 2156-29-8|2-di-1-asp

Introduction：Basic information about CAS 2156-29-8|2-di-1-asp, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 2-di-1-asp BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles32
6. Synonyms

Common Name	2-di-1-asp
CAS Number	2156-29-8	Molecular Weight	366.24000
Density	1.091g/cm3	Boiling Point	397.8℃at 760 mmHg
Molecular Formula	C₁₆H₁₉IN₂	Melting Point	280ºC (dec.)(lit.)
MSDS	USA	Flash Point	179.3℃
Symbol	GHS07	Signal Word	Warning

Names

Name	2-[4-(dimethylamino)styryl]-1-methylpyridinium iodide
Synonym	More Synonyms

2-di-1-asp BiologicalActivity

Description	2-Di-1-ASP (Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA[1].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
In Vitro	2-Di-1-ASP (Compound 18a) displays significant fluorescence enhancements in the presence of G-quadruplex (G4) structures (up to 300-fold), and good selectivity with respect to double-stranded DNA. 2-Di-1-ASP shows fluorimetric selectivity for parallel G4-DNA forms (c-kit2, c-kit87up, c-myc)[1].
References	[1]. Xie X, et al. Identification of optimal fluorescent probes for G-quadruplex nucleic acids through systematic exploration of mono- and distyryl dye libraries. Beilstein J Org Chem. 2019 Aug 6;15:1872-1889.

Chemical & Physical Properties

Density	1.091g/cm3
Boiling Point	397.8℃at 760 mmHg
Melting Point	280ºC (dec.)(lit.)
Molecular Formula	C₁₆H₁₉IN₂
Molecular Weight	366.24000
Flash Point	179.3℃
Exact Mass	366.05900
PSA	7.12000
Vapour Pressure	1.55E-06mmHg at 25°C
Index of Refraction	1.668
InChIKey	XPOIQAIBZGSIDD-UHFFFAOYSA-M
SMILES	CN(C)c1ccc(C=Cc2cccc[n+]2C)cc1.[I-]
Water Solubility	DMSO: soluble

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3

Articles32

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.

Proc. Natl. Acad. Sci. U. S. A. 105 , 9059-64, (2008)

The growing resistance to current first-line antimalarial drugs represents a major health challenge. To facilitate the discovery of new antimalarials, we have implemented an efficient and robust high-...

Distribution pattern of viable mitochondria in bovine lens epithelial cells.

Dev. Ophthalmol. 26 , 90-6, (1994)

Live-cell imaging of the cytoskeleton and mitochondrial-cytoskeletal interactions in budding yeast.

Methods Mol. Biol. 586 , 41-68, (2009)

This chapter describes labeling methods and optical approaches for live-cell imaging of the cytoskeleton and of a specific organelle-cytoskeleton interaction in budding yeast.

Synonyms

D-308

2-{2-[4-(dimethylamino)phenyl]ethenyl}-1-methylpyridinium iodide

2m2Pm

2-(4-(Dimethylamino)styryl)-N-methylpyridinium

MFCD00011980

o-DPD

2-<4-(dimethylamino)styryl>-1-ethylpyridinium iodide

2-(4-(dimethylamino)styryl)-1-methylpyridinium

(E)-2-(4-(dimethylamino)styryl)-1-methylpyridinium iodide

2-(4-DIMETHYLAMINOSTYRYL)-1-METHYLPYRIDINIUM IODIDE

2-DI-1-ASP

EINECS 218-460-8

1-METHYL-2-P-DIMETHYLAMINO-STYRYL-PYRIDINIUM-IODIDE

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