Introduction：Basic information about CAS 117977-21-6|Rabeprazole thioether, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Rabeprazole thioether |
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| CAS Number | 117977-21-6 | Molecular Weight | 343.443 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 546.4±60.0 °C at 760 mmHg |
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| Molecular Formula | C18H21N3O2S | Melting Point | 120.5-121.5ºC |
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| MSDS | / | Flash Point | 284.2±32.9 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | Rabeprazole Sulfide |
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| Synonym | More Synonyms |
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Rabeprazole thioether BiologicalActivity
| Description | Rabeprazole Sulfide is an active metabolite of Rabeprazole. Rabeprazole is a proton pump inhibitor that suppresses gastric acid secretion through an interaction with (H+/K+)-ATPase in gastric parietal cells. Rabeprazole markedly inhibits the motility of H. pylori. Rabeprazole has the potential for various peptic diseases treatment[1][2]. |
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| Related Catalog | Research Areas >>InfectionResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Membrane Transporter/Ion Channel >>Proton PumpSignaling Pathways >>Anti-infection >>Bacterial |
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| References | [1]. Uno T, et al. Determination of rabeprazole and its active metabolite, rabeprazole thioether in human plasma by column-switching high-performance liquid chromatography and its application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25;824(1-2):238-43. [2]. Tsutsui N, et al. A novel action of the proton pump inhibitor rabeprazole and its thioether derivative against the motility of Helicobacter pylori. Antimicrob Agents Chemother. 2000 Nov;44(11):3069-73. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 546.4±60.0 °C at 760 mmHg |
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| Melting Point | 120.5-121.5ºC |
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| Molecular Formula | C18H21N3O2S |
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| Molecular Weight | 343.443 |
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| Flash Point | 284.2±32.9 °C |
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| Exact Mass | 343.135437 |
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| PSA | 85.33000 |
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| LogP | 3.53 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.636 |
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| InChIKey | BSXAHDOWMOSVAP-UHFFFAOYSA-N |
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| SMILES | COCCCOc1ccnc(CSc2nc3ccccc3[nH]2)c1C |
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| Storage condition | -20°C Freezer |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H315-H319-H335 |
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| Precautionary Statements | P305 + P351 + P338 |
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| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio]benzimidazole |
| MFCD08063845 |
| 2-({[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl}sulfanyl)-1H-benzimidazole |
| 2-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole |
| 1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]- |
| 2-({[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfanyl)-1H-benzimidazole |
| 2-[[[4-(3-Methoxy Propoxy)-3-methyl pyridine-2-yl]methyl ] thio]-1H-benzimidazole |
| 2-[[[4-(3-Methoxy Propoxy)-3-methyl pyridine-2-yl ]methyl ] thio]-1H-benzimidazole |
| 2-(((4-(3-METHOXYPROPOXY)-3-METHYL-2-PYRIDINYL)METHYL)THIO)-1H-BENZIMIDAZOLE |
| 2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfanyl]-1H-benzimidazole |
