CAS 83701-22-8|Minoxidil sulphate
| Common Name | Minoxidil sulphate | ||
|---|---|---|---|
| CAS Number | 83701-22-8 | Molecular Weight | 289.311 |
| Density | / | Boiling Point | 732ºC at 760 mmHg |
| Molecular Formula | C9H15N5O4S | Melting Point | 175-180°C |
| MSDS | ChineseUSA | Flash Point | 396.5ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Minoxidil Sulfate |
|---|---|
| Synonym | More Synonyms |
Minoxidil sulphate BiologicalActivity
| Description | Minoxidil sulfate, a potent and ATP-sensitive K+ channel opener, is the sulfated metabolite of minoxidil. Minoxidil sulfate is considered as a vasodilator to promote hair growth in vivo[1][3]. |
|---|---|
| Related Catalog | Research Areas >>Metabolic DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
| Target | IC50: K channel[2] |
| In Vitro | Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration[2]. Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS[2]. Western Blot Analysis[2] Cell Line: Rat brain microvascular endothelial cells (RBMECs) Concentration: 0-100 μM Incubation Time: 15 mins, 30 mins, 1 hour, 2 hours, 4 hours Result: Induced RhoA activation and PKB phosphorylation at Ser-473. |
| References | [1]. A E Buhl, et al. Minoxidil sulfate is the active metabolite that stimulates hair follicles. J Invest Dermatol. 1990 Nov;95(5):553-7. [2]. Yan-ting Gu, et al. Minoxidil sulfate induced the increase in blood-brain tumor barrier permeability through ROS/RhoA/PI3K/PKB signaling pathway.Neuropharmacology 2013 Dec;75:407-15.doi: 10.1016/j.neuropharm. [3]. Y Nakaya, et al.Effect of minoxidil sulfate and pinacidil on single potassium channel current in cultured human outer root sheath cells and dermal papilla cells. J Dermatol Sci. 1994 Jul;7 Suppl:S104-8. |
Chemical & Physical Properties
| Boiling Point | 732ºC at 760 mmHg |
|---|---|
| Melting Point | 175-180°C |
| Molecular Formula | C9H15N5O4S |
| Molecular Weight | 289.311 |
| Flash Point | 396.5ºC |
| Exact Mass | 289.084473 |
| PSA | 146.86000 |
| LogP | 0.72080 |
| Storage condition | −20°C |
| Stability | Light Sensitive - Protect from Light, Store in Freezer |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933599090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles27
More Articles| Molecular biology of the human cytosolic sulfotransferase gene superfamily implicated in the bioactivation of minoxidil and cholesterol in skin. Exp. Dermatol. 8(4) , 328-9, (1999) Cytosolic sulfotransferases (ST) catalyze the sulfation of various phenolic agents, catecholamines, thyroid hormones, steroids, drugs, and procarcinogens, usually resulting in the inactivation and sub... | |
| Iontophoresis-targeted, follicular delivery of minoxidil sulfate for the treatment of alopecia. J. Pharm. Sci. 102(5) , 1488-94, (2013) Although minoxidil (MX) is a drug known to stimulate hair growth, the treatment of androgenic alopecia could be improved by delivery strategies that would favor drug accumulation into the hair follicl... | |
| Sulfation of minoxidil by multiple human cytosolic sulfotransferases. Chem. Biol. Interact. 109(1-3) , 53-67, (1998) Minoxidil is an antihypertensive agent and hair growth promoter that is metabolized by sulfation to the active compound, minoxidil sulfate. Thermostable phenol sulfotransferase (TS PST or P-PST) was i... |
Synonyms
| ({[2,6-Diamino-4-(1-piperidinyl)pyrimidin-1-ium-1-yl]oxy}sulfonyl)oxidanide |
| Pyrimidinium, 2,6-diamino-4-(1-piperidinyl)-1-(sulfooxy)-, inner salt |
| (2,6-diamino-4-piperidin-1-ylpyrimidin-1-ium-1-yl) sulfate |
| MFCD06248907 |
| Minoxidil sulphate |
