CAS 20570-96-1|Benzylhydrazine dihydrochloride

CHEMICAL IDENTIFICATION

RTECS NUMBER :

MU8540000

CHEMICAL NAME :

Hydrazine, benzyl-, dihydrochloride

CAS REGISTRY NUMBER :

20570-96-1

LAST UPDATED :

198910

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C7-H10-N2.2Cl-H

MOLECULAR WEIGHT :

195.11

WISWESSER LINE NOTATION :

ZM1R &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

11 mg/kg

TOXIC EFFECTS :

Behavioral - changes in motor activity (specific assay) Behavioral - antipsychotic

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

10 gm/kg/29W-C

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease

MUTATION DATA

TYPE OF TEST :

Mutation test systems - not otherwise specified

TEST SYSTEM :

Bacteria - Bacillus subtilis

DOSE/DURATION :

10 mmol/L

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 5,343,1968

J. Pharm. Sci. 74(1) , 105-7, (1985)

A GC procedure for the simultaneous determination of hydrazine and benzylhydrazine in isocarboxazid raw material and tablet formulations has been developed. The method is based on the reaction of benz...

Biochem. J. 260(1) , 19-25, (1989)

Bovine serum amine oxidase is inhibited by benzylhydrazine (BHy), but recovers full activity after a few hours incubation [Hucko-Haas & Reed (1970) Biochem. Biophys. Res. Commun. 38, 396-400]. The fir...

Bioorg. Med. Chem. 12(13) , 3649-55, (2004)

A series of indole-2-carboxylic acid benzylidene-hydrazides has been identified as a new class of potent apoptosis inducers through a novel cell-based caspase HTS assay. The screening hit, 5-chloro-3-...