CAS 83-05-6|4,4'-DDA

Introduction：Basic information about CAS 83-05-6|4,4'-DDA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
4. Safety Information
5. Customs
6. Articles25
7. Synonyms

Common Name	4,4'-DDA
CAS Number	83-05-6	Molecular Weight	281.13400
Density	1.373g/cm3	Boiling Point	411.4ºC at 760 mmHg
Molecular Formula	C₁₄H₁₀Cl₂O₂	Melting Point	167-169ºC(lit.)
MSDS	ChineseUSA	Flash Point	202.6ºC
Symbol	GHS07, GHS08	Signal Word	Warning

Names

Name	bis(4-chlorophenyl)acetic acid
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.373g/cm3
Boiling Point	411.4ºC at 760 mmHg
Melting Point	167-169ºC(lit.)
Molecular Formula	C₁₄H₁₀Cl₂O₂
Molecular Weight	281.13400
Flash Point	202.6ºC
Exact Mass	280.00600
PSA	37.30000
LogP	4.20990
Index of Refraction	1.616
InChIKey	YIOCIFXUGBYCJR-UHFFFAOYSA-N
SMILES	O=C(O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AF5475000

CHEMICAL NAME :: Acetic acid, bis(p-chlorophenyl)-

CAS REGISTRY NUMBER :: 83-05-6

BEILSTEIN REFERENCE NO. :: 1913593

LAST UPDATED :: 199706

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C14-H10-Cl2-O2

MOLECULAR WEIGHT :: 281.14

WISWESSER LINE NOTATION :: QYVR DG&R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 740 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Liver - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 590 mg/kg

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 250 mg/kg

SEX/DURATION :: female 15-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 350 mg/kg

SEX/DURATION :: female 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - rat Cells - not otherwise specified

DOSE/DURATION :: 150 mg/L/24H (Continuous)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,355,1972

Safety Information

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302 + H312 + H332-H351
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	7-22-36-45
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AF5475000
HS Code	2916399090

Customs

HS Code	2916399090
Summary	2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles25

Mitotane (1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane) metabolism in perfusion studies with dog adrenal glands.

Drug Metab. Dispos. 15(2) , 267-9, (1987)

Oxidation at C-1 controls the cytotoxicity of 1,1-dichloro-2,2- bis(p-chlorophenyl)ethane by rabbit and human lung cells.

Drug Metab. Dispos. 23(5) , 595-9, (1995)

Isolated rabbit Clara cells and a transformed human bronchial epithelial cell line, BEAS-2B, were used to investigate the mechanism of cytotoxicity of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD),...

Development of an enzyme-linked immunosorbent assay for the quantification of DDA (2,2-bis(p-chlorophenyl) acetic acid) in urine.

Bull. Environ. Contam. Toxicol. 38(5) , 798-804, (1987)

Synonyms

EINECS 201-451-8

MFCD00004248

Bis(4-chlorophenyl)acetic Acid

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