CAS 115453-82-2|7-Ethoxy-4-(trifluoromethyl)coumarin

Introduction：Basic information about CAS 115453-82-2|7-Ethoxy-4-(trifluoromethyl)coumarin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 7-Ethoxy-4-(trifluoromethyl)coumarin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles33
7. Synonyms

Common Name	7-Ethoxy-4-(trifluoromethyl)coumarin
CAS Number	115453-82-2	Molecular Weight	258.19300
Density	1.368 g/cm3	Boiling Point	303.1ºC at 760 mmHg
Molecular Formula	C₁₂H₉F₃O₃	Melting Point	/
MSDS	ChineseUSA	Flash Point	132.7ºC

Names

Name	7-ethoxy-4-(trifluoromethyl)chromen-2-one
Synonym	More Synonyms

7-Ethoxy-4-(trifluoromethyl)coumarin BiologicalActivity

Description	7-Ethoxy-4-trifluoromethylcoumarin is a fluorescent substrate of various enzymes of the cytochrome P450 superfamily[1]
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Morse MA, et al. High-performance liquid chromatographic method for measurement of cytochrome P450-mediated metabolism of 7-ethoxy-4-trifluoromethylcoumarin. J Chromatogr B Biomed Sci Appl. 1998 Apr 24;708(1-2):290-3.

Chemical & Physical Properties

Density	1.368 g/cm3
Boiling Point	303.1ºC at 760 mmHg
Molecular Formula	C₁₂H₉F₃O₃
Molecular Weight	258.19300
Flash Point	132.7ºC
Exact Mass	258.05000
PSA	39.44000
LogP	3.21050
Vapour Pressure	0.000952mmHg at 25°C
Index of Refraction	1.503
InChIKey	OLHOIERZAZMHGK-UHFFFAOYSA-N
SMILES	CCOc1ccc2c(C(F)(F)F)cc(=O)oc2c1
Storage condition	20°C

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
HS Code	2932209090

Customs

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles33

HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics.

Arch. Pharm. Res. 38 , 691-704, (2015)

Although various in vitro assays have been developed to evaluate the cytochrome P450 (CYP)-inducing potential of drug candidates, there is a continuing need for the development of a reliable model in ...

Environmentally persistent free radical-containing particulate matter competitively inhibits metabolism by cytochrome P450 1A2.

Toxicol. Appl. Pharmacol. 289 , 223-30, (2015)

Combustion processes generate different types of particulate matter (PM) that can have deleterious effects on the pulmonary and cardiovascular systems. Environmentally persistent free radicals (EPFRs)...

Inhibition of cytochrome P450 2B4 by environmentally persistent free radical-containing particulate matter.

Biochem. Pharmacol. 95 , 126-32, (2015)

Combustion processes generate particulate matter (PM) that can affect human health. The presence of redox-active metals and aromatic hydrocarbons in the post-combustion regions results in the formatio...

Synonyms

2H-1-Benzopyran-2-one,7-ethoxy-4-(trifluoromethyl)

7-Ethoxy-4-(trifluoromethyl)coumarin

Ethyl 4-(trifluoromethyl)umbelliferyl ether

7-Ethoxy-4-trifluoromethylcoumarin

Etfc cpd

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