CAS 198481-33-3|Bazedoxifene Acetate
| Common Name | Bazedoxifene Acetate | ||
|---|---|---|---|
| CAS Number | 198481-33-3 | Molecular Weight | 530.654 |
| Density | / | Boiling Point | 694.4ºC at 760 mmHg |
| Molecular Formula | C32H38N2O5 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 373.8ºC |
Names
| Name | Bazedoxifene acetate |
|---|---|
| Synonym | More Synonyms |
Bazedoxifene Acetate BiologicalActivity
| Description | Bazedoxifene acetate is a third generation selective estrogen receptor modulator (SERM) with IC50s of 26 and 99 nM for ERα and ERβ, respectively. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>Estrogen Receptor/ERRResearch Areas >>Cancer |
| Target | IC50: 26 nM (ERα), 99 nM (ERβ)[1] |
| References | [1]. Jaime Kulak, et al. Treatment with Bazedoxifene, a Selective Estrogen Receptor Modulator, Causes Regression of Endometriosis in a Mouse Model. Endocrinology. 2011; 152(8): 3226-3232. [2]. Hisaya Kawate, Ryoichi Takayanagi. Efficacy and safety of bazedoxifene for postmenopausal osteoporosis. Clin Interv Aging. 2011; 6: 151-160. [3]. Stefano Lello, et al. Bazedoxifene: literature data and clinical evidence. Clin Cases Miner Bone Metab. 2011; 8(3): 29-32. [4]. Joan S. Lewis-Wambi, Helen Kim, Ramona Curpan, et al. The Selective Estrogen Receptor Modulator Bazedoxifene Inhibits Hormone-Independent Breast Cancer Cell Growth and Down-Regulates Estrogen Receptor α and Cyclin D1. Mol Pharmacol. 2011 ; 80(4): 610-620. [5]. Diane M Biskobing. Update on bazedoxifene: A novel selective estrogen receptor modulator. Clin Interv Aging. 2007; 2(3): 299-303. |
Chemical & Physical Properties
| Boiling Point | 694.4ºC at 760 mmHg |
|---|---|
| Molecular Formula | C32H38N2O5 |
| Molecular Weight | 530.654 |
| Flash Point | 373.8ºC |
| Exact Mass | 530.278076 |
| PSA | 95.16000 |
| LogP | 6.35980 |
| Vapour Pressure | 6.33E-20mmHg at 25°C |
| InChIKey | OMZAMQFQZMUNTP-UHFFFAOYSA-N |
| SMILES | CC(=O)O.Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12 |
Safety Information
| RIDADR | NONH for all modes of transport |
|---|
Synonyms
| 1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, acetate (1:1) (salt) |
| 1-{4-[2-(Azepan-1-yl)ethoxy]benzyl}-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetate (1:1) |
| 1-{4-[2-(1-Azepanyl)ethoxy]benzyl}-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetate (1:1) |
| Bazedoxifene Acetate |
| acetic acid,1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol |
| Bazedoxifene (acetate) |
