Introduction：Basic information about CAS 20231-01-0|BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE |
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| CAS Number | 20231-01-0 | Molecular Weight | 350.59000 |
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| Density | 1.339g/cm3 | Boiling Point | 450.5ºC at 760 mmHg |
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| Molecular Formula | C12H22N4S4 | Melting Point | 142ºC |
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| MSDS | / | Flash Point | 226.3ºC |
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Names
| Name | (4-methylpiperazine-1-carbothioyl)sulfanyl 4-methylpiperazine-1-carbodithioate |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | EWP 815 is a disulfiram analogue, is a potent inhibitor of Ins(1,4)P2 phosphatase and Ins(1,4,5)P3 5-phosphatase. EWP 815 also inhibits enzyme dopamine β-hydroxylase activity[1][2]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>PhosphataseResearch Areas >>Others |
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| Target | Ins(1,4)P2 phosphatase; Ins(1,4,5)P3 5-phosphatase[1]; dopamine β-hydroxylase[2] |
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| In Vitro | EWP 815 inhibits thyrotropin-releasing hormone (TRH; 0.03 mM)-stimulated inositol phospholipid breakdown without affecting basal breakdown rates in prelabelled GH3 cells with IC50s of 83 mM (soluble enzymes) and 71 mM (particulate enzymes), respectively[1]. EWP 815 (30 μM; 1 h) exerts higher inhibition on Ins(1,4)P2 phosphatase rather than Ins(1,4,5)P3 5-phosphatase with the mean [3H]Ins(1,4)P2/mean [3H]InsP recovery ratio of 2.6[1]. EWP 815 (6, 8 μM; 10 min) inhibits dephosphorylation of [3H]Ins(1,4,5)P3 5-phosphatase in particulate and soluble fractions with IC50s of 6 μM and 8 μM, respectively[1]. EWP 815 (3-300 μM; 30 min) suppresses thyrotropin-releasing hormone (TRH)-stimulated (100 nM) inositol phospholipid production by 30% (100 μM) and 1.8% (300 μM), respectively, without affecting Ins(1,4,5)P3 binding[1]. |
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| In Vivo | EWP 815 (50 mg/kg; i.p.; 30 min before killed) inhibits the enzyme dopamine β-hydroxylase activity in mice[2]. Animal Model: Female mice (20 g)[2] Dosage: 50 mg/kg Administration: Intraperitoneal injection; 30 min before killed Result: Intraperitoneal injection; 30 min before killedInhibited β-hydroxylase of 3H-α-methyldopamine. Reduced the amount of 3H-α-Me-NA by 12%. |
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| References | [1]. Fowler CJ, et al. Inhibition of inositol 1,4,5-trisphosphate 5-phosphatase by micromolar concentrations of disulfiram and its analogues. Biochem J. 1993 Feb 1;289 ( Pt 3)(Pt 3):853-9. [2]. Carlsson A, et al. On the beta-hydroxylation of (+-)-alpha-methyldopamine in vivo. Eur J Pharmacol. 1968 Dec;5(1):85-92. |
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Chemical & Physical Properties
| Density | 1.339g/cm3 |
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| Boiling Point | 450.5ºC at 760 mmHg |
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| Melting Point | 142ºC |
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| Molecular Formula | C12H22N4S4 |
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| Molecular Weight | 350.59000 |
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| Flash Point | 226.3ºC |
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| Exact Mass | 350.07300 |
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| PSA | 127.74000 |
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| LogP | 1.18400 |
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| Vapour Pressure | 2.62E-08mmHg at 25°C |
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| Index of Refraction | 1.673 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- JO1527500
- CHEMICAL NAME :
- Disulfide, bis((4-methyl-1-piperazinyl)thiocarbonyl)
- CAS REGISTRY NUMBER :
- 20231-01-0
- BEILSTEIN REFERENCE NO. :
- 0893745
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C12-H22-N4-S4
- MOLECULAR WEIGHT :
- 350.62
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 15(Suppl 1),S82,1996
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 7,7,1970
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Safety Information
| Safety Phrases | S24/25 |
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| HS Code | 2933599090 |
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Customs
| HS Code | 2933599090 |
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| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Ewp 815 |
| Piperazine,1,1'-(dithiodicarbonothioyl)bis(4-methyl |
| bis((4-methylpiperazino)thiocarbamoyl)disulfide |
| MFCD01729803 |
| Bis((4-methyl-1-piperazinyl)thiocarbonyl)disulfide |
| Bis-<(4-methyl-1-piperazinyl)-thiocarbonyl>disulfid |
| DISULFIDE,BIS((4-METHYL-1-PIPERAZINYL)THIOCARBONYL) |
| 4-Methylpiperazino-thiuramdisulfide |
| bis-(4-methyl-piperazine-1-carbothioyl)-disulfane |
| 4,4'-dimethyl-1,1'-(2,3-dithia-butanedithioyl)-bis-piperazine |
| di-N-methylpiperazinethiuramdisulfide |
