CAS 26172-54-3|Methylisothiazolinone hydrochloride
| Common Name | Methylisothiazolinone hydrochloride | ||
|---|---|---|---|
| CAS Number | 26172-54-3 | Molecular Weight | 151.61500 |
| Density | / | Boiling Point | / |
| Molecular Formula | C4H6ClNOS | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS05, GHS08 | Signal Word | Danger |
Names
| Name | 2-Methyl-3-isothiazolone Hydrochloride |
|---|---|
| Synonym | More Synonyms |
Methylisothiazolinone hydrochloride BiologicalActivity
| Description | Methylisothiazolinone hydrochloride is the constituent of the biocide Kathon CG. Methylisothiazolinone hydrochloride is an isothiazolone derivative widely used as a preservative. Methylisothiazolinone hydrochloride is also a moderate sensitizer and reacts with GSH[1][2]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
| References | [1]. Rubén Alvarez-Sánchez, et al. Covalent Binding of the 13C-labeled Skin Sensitizers 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI) to a Model Peptide and Glutathione. Bioorg Med Chem Lett. 2004 Jan 19;14(2):365-8. [2]. Aynur O Aptula, et al. From Experiment to Theory: Molecular Orbital Parameters to Interpret the Skin Sensitization Potential of 5-chloro-2-methylisothiazol-3-one and 2-methylisothiazol-3-one. Chem Res Toxicol. 2005 Feb;18(2):324-9. |
Chemical & Physical Properties
| Molecular Formula | C4H6ClNOS |
|---|---|
| Molecular Weight | 151.61500 |
| Exact Mass | 150.98600 |
| PSA | 50.24000 |
| LogP | 1.24880 |
| InChIKey | SJXPQSRCFCPWQQ-UHFFFAOYSA-N |
| SMILES | Cl.Cn1sccc1=O |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS05, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H314-H317-H334 |
| Precautionary Statements | P261-P280-P305 + P351 + P338-P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | C |
| Risk Phrases | 34-42/43 |
| Safety Phrases | 26-36/37/39-45 |
| RIDADR | UN 1759 8/PG 2 |
| WGK Germany | 3 |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles31
More Articles| Methylisothiazolinone contact allergy and dose-response relationships. Contact Dermatitis 64(6) , 330-6, (2011) Methylisothiazolinone (MI) used alone is a new preservative causing a high prevalence of contact allergy. The eliciting threshold of MI is unknown. The combination of MI and phenoxyethanol enhances th... | |
| Biocide immobilized OMMT-carbon dot reduced Cu2O nanohybrid/hyperbranched epoxy nanocomposites: Mechanical, thermal, antimicrobial and optical properties. Mater. Sci. Eng. C. Mater. Biol. Appl. 56 , 74-83, (2015) The present work demonstrated a transparent thermosetting nanocomposite with antimicrobial and photoluminescence attributes. The nanocomposites are fabricated by incorporation of different wt.% (1, 2 ... | |
| Follow-up of the monitored levels of preservative sensitivity in Europe: overview of the years 2001-2008. Contact Dermatitis 67(5) , 312-4, (2012) |
Synonyms
| 2-Methyl-3-isothiazoloneHydrochloride |
| MIT,Methylisothiazolinone hydrochloride |
| 2-methyl-1,2-thiazol-3-one,hydrochloride |
| EINECS 247-499-3 |
| MFCD06804636 |
