CAS 53411-70-4|Trisodium 6-O-phosphonato-D-gluconate
Introduction：Basic information about CAS 53411-70-4|Trisodium 6-O-phosphonato-D-gluconate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
6-Phosphogluconic acid trisodium is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite[1][2].
Related Catalog
Research Areas >>Metabolic Disease
Target
phosphoglucose isomerase[1]
In Vitro
6-Phosphogluconic acid trisodium (0.5-2.0 mM) completely inhibits the activity of PGI with glucose 6-phosphate (0.05- 0.5 mM) as the substrate[1].
References
[1]. Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52(5):1348-52.
[2]. Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600.
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%
Articles4
More Articles
A spectrophotometric method for the determination of creatine phosphokinase and myokinase.
Biochem. J. 61 , 116-22, (1955)
Direct oxidation of glucose-6-phosphate by animal tissues.
Nature 166 , 33, (1950)
A new phosphorylated intermediate in glucose oxidation.
J. Biol. Chem. 210 , 617-626, (1954)
Synonyms
D-Gluconic acid, 6-(dihydrogen phosphate), sodium salt (1:3)
