CAS 12141-67-2|POM 1
| Common Name | POM 1 | ||
|---|---|---|---|
| CAS Number | 12141-67-2 | Molecular Weight | 2986.01 |
| Density | 3.1 g/cm3 | Boiling Point | / |
| Molecular Formula | H2Na6O40W12 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS05 | Signal Word | Danger |
Names
| Name | sodium metatungstate |
|---|---|
| Synonym | More Synonyms |
POM 1 BiologicalActivity
| Description | POM1 is a potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1, NTPDase 3 and NTPDase 2 respectively[1]. POM1 inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| Target | Ki: 2.58 μM (NTPDase 1), 3.26 μM (NTPDase 3), 28.8 μM (NTPDase 2)[1]. |
| References | [1]. Müller CE, et al. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5943-7. [2]. Wall et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacology. 2008 Dec;55(7):1251-8. |
Chemical & Physical Properties
| Density | 3.1 g/cm3 |
|---|---|
| Molecular Formula | H2Na6O40W12 |
| Molecular Weight | 2986.01 |
| Exact Mass | 2969.15000 |
| PSA | 701.67000 |
| Index of Refraction | n20/D 1.5555 |
| Storage condition | Store at RT |
| Water Solubility | Soluble in water. |
Safety Information
| Symbol | GHS05 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H318-H412 |
| Precautionary Statements | P273-P280-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | 26-39-61 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
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Synonyms
| SODIUM POLYTUNGSTATE |
| POM 1 |
| 4-Acetyl-1,1-dimethylpiperazinium iodide |
| Sodium metatungstate monohydrate |
| EINECS 412-770-9 |
| Sodium metatungstate |
| SODIUM POLYTINGSTATE |
| hexasodium tungstate hydrate |
| Sodium polytungstate solution |
| TUNGSTATEHEXASODIUM |
| MFCD00061466 |
