Introduction：Basic information about CAS 73963-62-9|3,4-Dehydro Cilostazol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3,4-Dehydro Cilostazol |
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| CAS Number | 73963-62-9 | Molecular Weight | 367.44500 |
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| Density | 1.342g/cm3 | Boiling Point | 675.937ºC at 760 mmHg |
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| Molecular Formula | C20H25N5O2 | Melting Point | 179-180ºC |
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| MSDS | USA | Flash Point | 362.594ºC |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | 6-[4-(1-cyclohexyltetrazol-5-yl)butoxy]-1H-quinolin-2-one |
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| Synonym | More Synonyms |
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3,4-Dehydro Cilostazol BiologicalActivity
| Description | 3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol (CLZ; HY-17464). 3,4-Dehydro Cilostazol is used for pharmacokinetic study[1]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>Cardiovascular Disease |
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| In Vivo | 3,4-Dehydro Cilostazol (OPC-13015; Oral; 1 mg/kg GLZ and 10 mg/kg CLZ) has a T1/2 of 3.94 hours, a Cmax of 1.39 μM and an AUC0-24 of 4.69 μg•h/ml. The plasma concentration time profiles of GLZ, CLZ & its active metabolite DCLZ are traceable up to 24 h, 12 h and 12 h respectively by oral administration at 1 mg/kg dose of GLZ and 10 mg/kg CLZ[1]. Animal Model: Male Wistar rats weighing 200 g[1] Dosage: 1 mg/kg Glipizide (GLZ) and 10 mg/kg Cilostazol (CLZ) (Pharmacokinetic Analysis) Administration: Oral Result: Had a T1/2 of 3.94 hours, a Cmax of 1.39 μM and an AUC0-24 of 4.69 μg•h/ml. |
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| References | [1]. T R S Satheeshmanikandan, et al. Liquid Chromatography - Tandem Mass Spectrometry for the Simultaneous Quantitation of Glipizide, Cilostazol and Its Active Metabolite 3, 4-dehydro-cilostazol in Rat Plasma: Application for a Pharmacokinetic Study. Arzneimittelforschung. 2012 Sep;62(9):425-32. |
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Chemical & Physical Properties
| Density | 1.342g/cm3 |
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| Boiling Point | 675.937ºC at 760 mmHg |
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| Melting Point | 179-180ºC |
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| Molecular Formula | C20H25N5O2 |
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| Molecular Weight | 367.44500 |
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| Flash Point | 362.594ºC |
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| Exact Mass | 367.20100 |
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| PSA | 85.69000 |
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| LogP | 3.42150 |
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| Index of Refraction | 1.676 |
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| InChIKey | GHALECSGOJQOHW-UHFFFAOYSA-N |
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| SMILES | O=c1ccc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2[nH]1 |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H302 |
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| Precautionary Statements | P301 + P312 + P330 |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| 3,4-dehydro-cilostazol |
| UNII-5M77W4SPE0 |
| QUI006 |
