CAS 85571-15-9|Rhodionin

Introduction：Basic information about CAS 85571-15-9|Rhodionin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Rhodionin BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Rhodionin
CAS Number	85571-15-9	Molecular Weight	448.377
Density	1.7±0.1 g/cm3	Boiling Point	802.9±65.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₀O₁₁	Melting Point	/
MSDS	/	Flash Point	284.4±27.8 °C

Names

Name	3,5,8-trihydroxy-2-(4-hydroxyphenyl)-7-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxychromen-4-one
Synonym	More Synonyms

Rhodionin BiologicalActivity

Description	Rhodionin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.761 μM and a Ki of 0.769 μM[1]. Rhodionin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50 to 2.43 μg/mL[2]. Rhodionin exhibits potent DPPH free radical scavenging activities, with an IC50 of 19.49 μM[3].
Related Catalog	Research Areas >>Metabolic DiseaseSignaling Pathways >>Neuronal Signaling >>AChE
Target	IC50: 0.761 μM (cytochrome P450 2D6)[1]；57.50-2.43 μg/mL (AChE)[2]；19.49 μM (DPPH free radical scavenging)[3]
References	[1]. Xu W, et al. Two potent cytochrome P450 2D6 inhibitors found in Rhodiola rosea. Pharmazie. 2013 Dec;68(12):974-6. [2]. Li FJ, et al. Molecular interaction studies of acetylcholinesterase with potential acetylcholinesterase inhibitors from the root of Rhodiola crenulata using molecular docking and isothermal titration calorimetry methods. Int J Biol Macromol. 2017 Nov;104(Pt A):527-532. [3]. Choe KI, et al. The antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of Rhodiola sachalinensis A. BOR. Molecules. 2012 Sep 27;17(10):11484-94.

Chemical & Physical Properties

Density	1.7±0.1 g/cm3
Boiling Point	802.9±65.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₀O₁₁
Molecular Weight	448.377
Flash Point	284.4±27.8 °C
Exact Mass	448.100555
PSA	190.28000
LogP	0.44
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.755
InChIKey	CIAXXTSXVCLEJK-JOEVVYSCSA-N
SMILES	CC1OC(Oc2cc(O)c3c(=O)c(O)c(-c4ccc(O)cc4)oc3c2O)C(O)C(O)C1O
Storage condition	2-8℃

Synonyms

3,5,8-Trihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl 6-deoxy-α-L-mannopyranoside

4H-1-Benzopyran-4-one, 7-[(6-deoxy-α-L-mannopyranosyl)oxy]-3,5,8-trihydroxy-2-(4-hydroxyphenyl)-

Herbacetin-7-O-|A-L-rhamnopyranoside

Herbacetin 7-rhamnoside

Herbacetin-7-O-α-L-rhamnopyranoside

Rhodionin

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