Introduction：Basic information about CAS 38971-41-4|Ophiopogonin B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ophiopogonin B |
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| CAS Number | 38971-41-4 | Molecular Weight | 722.902 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 835.7±65.0 °C at 760 mmHg |
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| Molecular Formula | C39H62O12 | Melting Point | / |
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| MSDS | / | Flash Point | 459.2±34.3 °C |
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Names
| Name | ophiopogonin B |
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| Synonym | More Synonyms |
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Ophiopogonin B BiologicalActivity
| Description | Ophiopogonin B induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway. Ophiopogonin B is a saponin compound isolated from Radix Ophiopogonjaponicus[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>MAPK/ERK Pathway >>JNK |
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| Target | JNK |
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| In Vitro | Ophiopogonin B (0, 5, 10and 20 μM) suppresses the proliferation of HT-29 and HCT-116 cell lines through the G0/G1 phase cell cycle arrest[1]. Ophiopogonin B induces apoptosis by inhibiting the expression of Bax and cleaved caspase 3 and promoting the expression of Bcl-2. Treatment with Ophiopogonin B also increases the expression of Beclin 1 and the conversion of LC3I to LC3II with the activation of JNK/c-Jun signaling pathway[1]. |
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| References | [1]. Gao GY, et al. Ophiopogonin B induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway. Biomed Pharmacother. 2018 Dec;108:1208-1215. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 835.7±65.0 °C at 760 mmHg |
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| Molecular Formula | C39H62O12 |
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| Molecular Weight | 722.902 |
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| Flash Point | 459.2±34.3 °C |
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| Exact Mass | 722.424133 |
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| PSA | 176.76000 |
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| LogP | 5.63 |
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| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
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| Index of Refraction | 1.604 |
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| InChIKey | OWGURJWJHWYCIQ-AKYREZHBSA-N |
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| SMILES | CC1CCC2(OC1)OC1CC3C4CC=C5CC(O)CC(OC6OC(C)C(O)C(O)C6OC6OC(C)C(O)C(O)C6O)C5(C)C4CCC3(C)C1C2C |
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Safety Information
Synonyms
| α-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl 6-deoxy-2-O-(6-deoxy-α-L-mannopyranosyl)- |
| 4-Octacosanone,24-hydroxy |
| 24-hydroxy-4-octacosanone |
| (1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-2-O-(6-deoxy-α-L-mannopyranosyl)-α-D-galactopyranoside |
