Introduction：Basic information about CAS 80018-06-0|Fengabine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fengabine |
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| CAS Number | 80018-06-0 | Molecular Weight | 322.22900 |
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| Density | 1.24g/cm3 | Boiling Point | 442.2ºC at 760 mmHg |
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| Molecular Formula | C17H17Cl2NO | Melting Point | / |
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| MSDS | / | Flash Point | 221.2ºC |
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Names
| Name | (6Z)-6-[butylamino-(2-chlorophenyl)methylidene]-4-chlorocyclohexa-2,4-dien-1-one |
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| Synonym | More Synonyms |
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Fengabine BiologicalActivity
| Description | Fengabine is a GABAergic antidepressant drug. Fengabine can be used for the research of depression[1]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor |
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| In Vivo | Fengabine (50 mg/kg; i.p.; 2 days) prevents completely the learned helplessness induced by the unavoidable shock[1]. Fengabine (150 mg/kg; i.p) decreases the percentage of time spent. Fengabine (25~50 mg/kg; i.p.) reverses the deficit in learning the step-down avoidance task[1]. Animal Model: Rats Dosage: 50 mg/kg Administration: I.p. Result: Prevented completely the learned helplessness induced by the unavoidable shock. |
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| References | [1]. Ascalone V, et al. Determination of the GABAergic antidepressant drug fengabine and some of its metabolites in plasma by capillary gas chromatography with electron-capture detection. J Chromatogr. 1989;490(1):81-90. [2]. Lloyd KG, et al. Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile. J Pharmacol Exp Ther. 1987;241(1):245-250. |
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Chemical & Physical Properties
| Density | 1.24g/cm3 |
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| Boiling Point | 442.2ºC at 760 mmHg |
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| Molecular Formula | C17H17Cl2NO |
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| Molecular Weight | 322.22900 |
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| Flash Point | 221.2ºC |
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| Exact Mass | 321.06900 |
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| PSA | 32.59000 |
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| LogP | 5.33650 |
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| Index of Refraction | 1.598 |
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| InChIKey | ZGLIFVFRIOKQLE-UHFFFAOYSA-N |
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| SMILES | CCCCN=C(c1cc(Cl)ccc1O)c1ccccc1Cl |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- SK1253333
- CHEMICAL NAME :
- Phenol, 2-((butylimino)(2-chlorophenyl)methyl)-4-chloro-
- CAS REGISTRY NUMBER :
- 80018-06-0
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C17-H17-Cl2-N-O
- MOLECULAR WEIGHT :
- 322.25
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2068960
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Synonyms
| SL 79-229 |
| FENGABINE |
| Fengabinum |
| Fengabina |
