Introduction：Basic information about CAS 671-88-5|Desamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Desamide |
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| CAS Number | 671-88-5 | Molecular Weight | 284.74000 |
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| Density | 1.621g/cm3 | Boiling Point | 549.4ºC at 760 mmHg |
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| Molecular Formula | C7H9ClN2O4S2 | Melting Point | / |
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| MSDS | / | Flash Point | 286.1ºC |
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Names
| Name | 4-chloro-6-methylbenzene-1,3-disulfonamide |
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| Synonym | More Synonyms |
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Desamide BiologicalActivity
| Description | Disulfamide, an orally active diuretic, is a carbonic anhydrase inhibitor with the IC50 value of 0.07 μM. Disulfamide leads to diuresis by inhibiting carbonic anhydrase and preventing the reabsorption of sodium and bicarbonate in the proximal tubule[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Carbonic AnhydraseResearch Areas >>Metabolic Disease |
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| Target | IC50: 0.07 μM (carbonic anhydrase)[1] |
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| In Vivo | Disulfamide (intraperitoneal injection, 200 mg/kg, once) has potential blood glucose raising properties in male Wistar rats[2]. Animal Model: Male Wistar rats weighing between 200-300 g[2] Dosage: 200 mg/kg Administration: Intraperitoneal injection; once Result: Resulted in elevated blood sugar levels from an initial blood glucose concentration of 143.1 mg/100 mL to a one hour later final concentration of 194.6 mg/100 mL, an increase of 36%. |
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| References | [1]. CT Supuran, et al. Carbonic anhydrase inhibitors: Synthesis and inhibitory properties of 1,3,4-thiadiazole-2,5-bissulfonamide. European Journal of Medicinal Chemistry,Volume 31, Issue 11, 1996, Pages 843-846. [2]. J M Foy, et al. Acute diuretic induced hyperglycaemia in rats. Life Sci. 1967 May 1;6(9):897-902. |
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Chemical & Physical Properties
| Density | 1.621g/cm3 |
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| Boiling Point | 549.4ºC at 760 mmHg |
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| Molecular Formula | C7H9ClN2O4S2 |
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| Molecular Weight | 284.74000 |
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| Flash Point | 286.1ºC |
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| Exact Mass | 283.96900 |
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| PSA | 137.08000 |
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| LogP | 3.50540 |
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| Index of Refraction | 1.612 |
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| InChIKey | RCFKEIREOSXLET-UHFFFAOYSA-N |
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| SMILES | Cc1cc(Cl)c(S(N)(=O)=O)cc1S(N)(=O)=O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- XT2220000
- CHEMICAL NAME :
- Toluene-2,4-disulfonamide, 5-chloro-
- CAS REGISTRY NUMBER :
- 671-88-5
- BEILSTEIN REFERENCE NO. :
- 2702245
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C7-H9-Cl-N2-O4-S2
- MOLECULAR WEIGHT :
- 284.75
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 56(4),134S,1960
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Synonyms
| Diuroblitz |
| 5-chloro-toluene-2,4-disulfonic acid diamide |
| Edemil |
| Desamide |
| Tolclotidum |
| Disulphamide |
| 5-Chlor-toluol-2,4-disulfonsaeure-diamid |
| Toluidrin |
| 6-Chlor-4-methyl-benzol-1,3-disulfonsaeurediamid |
| 5-Chlor-toluol-2,4-disulfonamid |
| Disamide |
| Toluren |
| Ethacrynic acid |
| Disulfamide |
| Fisiuretik |
