CAS 2002-35-9|n6-methyl-2'-deoxy-adenosine
| Common Name | n6-methyl-2'-deoxy-adenosine | ||
|---|---|---|---|
| CAS Number | 2002-35-9 | Molecular Weight | 265.27 |
| Density | 1.72g/cm3 | Boiling Point | 603.6ºC at 760mmHg |
| Molecular Formula | C11H15N5O3 | Melting Point | / |
| MSDS | USA | Flash Point | 318.8ºC |
Names
| Name | (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol |
|---|---|
| Synonym | More Synonyms |
n6-methyl-2'-deoxy-adenosine BiologicalActivity
| Description | N-6-Methyl-2-deoxyadenosine is an adenine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/AnalogResearch Areas >>Others |
| References | [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. |
Chemical & Physical Properties
| Density | 1.72g/cm3 |
|---|---|
| Boiling Point | 603.6ºC at 760mmHg |
| Molecular Formula | C11H15N5O3 |
| Molecular Weight | 265.27 |
| Flash Point | 318.8ºC |
| Exact Mass | 265.11700 |
| PSA | 105.32000 |
| Appearance of Characters | Powder | White to Off-white |
| Vapour Pressure | 2.03E-15mmHg at 25°C |
| Index of Refraction | 1.78 |
| InChIKey | DYSDOYRQWBDGQQ-XLPZGREQSA-N |
| SMILES | CNc1ncnc2c1ncn2C1CC(O)C(CO)O1 |
| Storage condition | −20°C |
| Water Solubility | Soluble in water |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 29349990 |
Articles7
More Articles| Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium. Br. J. Pharmacol. 171(14) , 3404-19, (2014) Despite the abundant expression of the UDP-sensitive P2Y6 receptor in urothelial cells and sub-urothelial myofibroblasts its role in the control of bladder function is not well understood.We compared ... | |
| GABA-mediated modulation of ATP-induced intracellular calcium responses in nodose ganglion neurons of the rat. Neurosci. Lett. 584 , 168-72, (2014) We examined ATP-induced intracellular Ca(2+) ([Ca(2+)]i) responses in the neurons and satellite cells from one of the viscerosensory ganglia, the nodose ganglion (NG), as well as the GABA-mediated mod... | |
| Pharmacological characterization of the human P2Y13 receptor. Mol. Pharmacol. 64 , 104-112, (2003) The P2Y13 receptor has recently been identified as a new P2Y receptor sharing a high sequence homology with the P2Y12 receptor as well as similar functional properties: coupling to Gi and responsivene... |
Synonyms
| N-6-methyl-2'-deoxyribofuranosil adenine |
| N6-Methyl-2'-desoxy-adenosin |
| N6-Methyldeoxyadenosine |
| 2'-Deoxy-N6-methylado |
| Adenosine,2'-deoxy-N-methyl |
| N6-Methyl-2'-deoxyadenosine |
| 2'-deoxy-N6-methyladenosine |
| N6-methyl-2'-deoxy-adenosine |
