Introduction：Basic information about CAS 5351-17-7|ZMVR DZ, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
4-Aminobenzohydrazide is an irreversible MPO myeloperoxidase inhibitor with an IC50 of 0.3 µM[1]. It is used for the research of subacute stroke[2].
Related Catalog
Research Areas >>Neurological Disease
References
[1]. Kettle AJ, et al. Inhibition of myeloperoxidase by benzoic acid hydrazides. Biochem J. 1995 Jun 1;308 ( Pt 2)(Pt 2):559-63.
[2]. Forghani R, et al. Myeloperoxidase propagates damage and is a potential therapeutic target for subacute stroke. J Cereb Blood Flow Metab. 2015 Mar;35(3):485-93.
Chemical & Physical Properties
Density
1.3±0.1 g/cm3
Melting Point
225-227 °C(lit.)
Molecular Formula
C7H9N3O
Molecular Weight
151.17
Exact Mass
151.074554
PSA
81.14000
LogP
-0.75
Index of Refraction
1.641
InChIKey
WPBZMCGPFHZRHJ-UHFFFAOYSA-N
SMILES
NNC(=O)c1ccc(N)cc1
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
DG2580000
CHEMICAL NAME :
Benzoic acid, p-amino-, hydrazide
CAS REGISTRY NUMBER :
5351-17-7
BEILSTEIN REFERENCE NO. :
0639053
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H9-N3-O
MOLECULAR WEIGHT :
151.19
WISWESSER LINE NOTATION :
ZNUYQR DZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01358
Safety Information
Personal Protective Equipment
dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes
Xi:Irritant;
Risk Phrases
R36/37/38
Safety Phrases
S26-S36
RIDADR
NONH for all modes of transport
WGK Germany
3
RTECS
DG2580000
HS Code
2928000090
Customs
HS Code
2928000090
Summary
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
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