CAS 19685-10-0|(4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]

Introduction：Basic information about CAS 19685-10-0|(4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b], including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name(4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAS Number19685-10-0Molecular Weight378.378
Density1.5±0.1 g/cm3Boiling Point773.1±60.0 °C at 760 mmHg
Molecular FormulaC21H18N2O5Melting Point/
MSDS/Flash Point421.4±32.9 °C

Names

Name9-methoxycamptothecine
SynonymMore Synonyms

BiologicalActivity

Description10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines[1].
Related CatalogResearch Areas >>CancerSignaling Pathways >>Others >>Others
References

[1]. Zheng J, et al. Development and validation of a RP-HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:81-7.

Chemical & Physical Properties

Density1.5±0.1 g/cm3
Boiling Point773.1±60.0 °C at 760 mmHg
Molecular FormulaC21H18N2O5
Molecular Weight378.378
Flash Point421.4±32.9 °C
Exact Mass378.121582
PSA90.65000
LogP1.69
Vapour Pressure0.0±2.8 mmHg at 25°C
Index of Refraction1.723
InChIKeyKLFJSYOEEYWQMR-NRFANRHFSA-N
SMILESCCC1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3cc(OC)ccc3nc2-1
Storage condition2-8C

Synonyms

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-9-methoxy-, (4S)-
(4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
10-methoxycamptothecin
10-MethoxycaMptothecine
CAS 869973-96-6|(1-METHYL-1H-PYRAZOL-3-YL)BORONIC ACID
CAS 509-20-6|ACONINE
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