Introduction：Basic information about CAS 386704-15-0|methyl 3-oxo-3-(6-(trifluoromethyl)pyridin-3-yl)propanoate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | methyl 3-oxo-3-(6-(trifluoromethyl)pyridin-3-yl)propanoate |
|---|
| CAS Number | 386704-15-0 | Molecular Weight | 247.17100 |
|---|
| Density | 1.341g/cm3 | Boiling Point | 295.5ºC at 760 mmHg |
|---|
| Molecular Formula | C10H8F3NO3 | Melting Point | 60-62ºC |
|---|
| MSDS | / | Flash Point | 132.5ºC |
|---|
Names
| Name | methyl 3-oxo-3-[6-(trifluoromethyl)pyridin-3-yl]propanoate |
|---|
| Synonym | More Synonyms |
|---|
BiologicalActivity
| Description | 11β-HSD1-IN-8 (compound c6a) is a 11β‑HSD1 inhibitor with an IC50 value of 2.3 μM for human 11β‑HSD1. 11β-HSD1-IN-8 can be used for the research of diabetes and cognitive decline[1]. |
|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic DiseaseResearch Areas >>Neurological Disease |
|---|
| Target | IC50: 2.3 μM (human 11β‑HSD)[1] |
|---|
| In Vitro | 11β-HSD1-IN-8 (0-50 μM) inhibits human and rat 11β‑HSD1 with IC50 values of 2.3 μM and ＞50 μM, respectively[1]. |
|---|
Chemical & Physical Properties
| Density | 1.341g/cm3 |
|---|
| Boiling Point | 295.5ºC at 760 mmHg |
|---|
| Melting Point | 60-62ºC |
|---|
| Molecular Formula | C10H8F3NO3 |
|---|
| Molecular Weight | 247.17100 |
|---|
| Flash Point | 132.5ºC |
|---|
| Exact Mass | 247.04600 |
|---|
| PSA | 56.26000 |
|---|
| LogP | 1.84620 |
|---|
| Index of Refraction | 1.459 |
|---|
| InChIKey | YXRIRKKHNGRGRZ-UHFFFAOYSA-N |
|---|
| SMILES | COC(=O)CC(=O)c1ccc(C(F)(F)F)nc1 |
|---|
Safety Information
| Hazard Codes | Xi |
|---|
| HS Code | 2933399090 |
|---|
Customs
| HS Code | 2933399090 |
|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|---|
Synonyms
