Introduction：Basic information about CAS 67483-13-0|DIDS sodium salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | DIDS sodium salt |
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| CAS Number | 67483-13-0 | Molecular Weight | 498.484 |
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| Density | 1.54g/cm3 | Boiling Point | 397ºC |
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| Molecular Formula | C16H8N2Na2O6S4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Benzenesulfonic acid, 2,2'-(1,2-ethenediyl)bis[5-isothiocyanato-, disodium salt |
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| Synonym | More Synonyms |
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DIDS sodium salt BiologicalActivity
| Description | DIDS sodium salt is a dual ABCA1 and VDAC1 inhibitor. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>OthersDye Reagents |
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| Target | ABCA1[1], VDAC1[2]. |
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| In Vitro | Concentration less than 400 μM DIDS has no evident cytotoxic effect on cell viability Pre-treatment with DIDS at the concentration of 100 and 200 μM result in a prevented effect on ALA-SDT-induced cell death, while dose at 50 μM has no inhibition effect. At the concentration of 400 μM DIDS itself slightly decreases the cell viability, although there is no significant statistic difference as compared with the untreated control. Pre-treatment with DIDS (100 μM) clearly inhibit caspase-3 and caspase-9 activation[2]. |
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| Cell Assay | Cells (5×105 cells/mL) are seeded in the 35-mm Petri dishes and cultured for 72 h at 37°C. Cells are pre-incubated with ALA, and then DIDS of diverse concentrations (0-200 μM) is added before exposed to ultrasound. Cell apoptosis is detected. Briefly, seeded cells (5×105 cells/mL) are pre-treated with test compounds at the indicated concentrations for 1 h (DIDS and NAC), 1.5 h (BAPTA) or with siRNA and exposed to ultrasound. Six hours after ALA-SDT treatment, cells are collected[2]. |
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| References | [1]. Tsou CY, et al. Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis. Acta Physiol (Oxf). 2014 Apr;210(4):799-810. [2]. Chen H, et al. Inhibition of VDAC1 prevents Ca²⁺-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages. Apoptosis. 2014 Dec;19(12):1712-26. |
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Chemical & Physical Properties
| Density | 1.54g/cm3 |
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| Boiling Point | 397ºC |
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| Molecular Formula | C16H8N2Na2O6S4 |
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| Molecular Weight | 498.484 |
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| Exact Mass | 497.906067 |
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| PSA | 214.40000 |
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| LogP | 5.98060 |
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| InChIKey | GEPAYBXVXXBSKP-SEPHDYHBSA-L |
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| SMILES | O=S(=O)([O-])c1cc(N=C=S)ccc1C=Cc1ccc(N=C=S)cc1S(=O)(=O)[O-].[Na+].[Na+] |
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Safety Information
| Hazard Codes | Xn: Harmful; |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | 22-26 |
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Synonyms
| DisodiuM 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonate |
| 4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID DISODIUM SALT |
| Benzenesulfonic acid, 2,2'-[(E)-1,2-ethenediyl]bis[5-isothiocyanato-, sodium salt (1:2) |
| 4,4'-diisothiocyanato-2,2'-stilbenedisulfonic acid sodium |
| Disodium 2,2'-[(E)-1,2-ethenediyl]bis(5-isothiocyanatobenzenesulfonate) |
| DISODIUM 4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISULFONATE |
| Hydrate [Protein Modification Reagent] |
| 4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID,2NA |
| PMPA (NMDA antagonist) |
| Disodium 2,2'-(E)-ethene-1,2-diylbis(5-isothiocyanatobenzenesulfonate) |
| DIDS |
| MFCD00009638 |
| DIDS DISODIUM SALT |
| 4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC A. NA2-SLT HY |
| DIDS sodium salt |
